Registration Dossier
Registration Dossier
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EC number: 254-487-1 | CAS number: 39515-51-0
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Test procedure in accordance with national standard methods with acceptable restrictions.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 977
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- m-phenoxybenzaldehyde
- EC Number:
- 254-487-1
- EC Name:
- m-phenoxybenzaldehyde
- Cas Number:
- 39515-51-0
- Molecular formula:
- C13H10O2
- IUPAC Name:
- 3-phenoxybenzaldehyde
- Details on test material:
- No information on purity available
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- corn oil
- Doses:
- 0.215, 0.464, 1.00, 2.15 and 4.64 ml(kg bw
- No. of animals per sex per dose:
- 5 males each
- Control animals:
- no
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 0.794 mL/kg bw
- Based on:
- test mat.
- 95% CL:
- 0.584 - 1.08
- Mortality:
- 1 ml/kg dose group: 4 out of 5 animals died. In the 2.15 and 4.64 ml/kg dose group all animals died.
- Clinical signs:
- other: Rats appeared markedly depressed and exhibited depressed righting and placement and absent pain reflexes, labored respiration, salivation, blood stains around the muzzles, inkempt fur coats, intermittent tremors. The higher the dosing the more intensified
- Gross pathology:
- Gross necropsy revealed, externally, slight amount of salivation and blood stains around the muzzles of four rats, urine stains on three rats, and unkempt fur on two rats; internally, all rats exhibited congested lungs, adrenals, and kidneys, irritated to hemorrhagic intestines filled with bloody fluid or fluid resembling the sample, diffusely pale livers, irritated and wrinkled peritoneal walls, and slight to advanced autolysis. No other gross pathological alterations were observed
Applicant's summary and conclusion
- Interpretation of results:
- harmful
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
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