Registration Dossier
Registration Dossier
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EC number: 254-898-6 | CAS number: 40379-24-6
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Data is from peer reviewed journal
Data source
Reference
- Reference Type:
- publication
- Title:
- Fragrance material review on isoamyl salicylate
- Author:
- A. Lapczynski , L. Jones, D. McGinty, S. Bhatia, C.S. Letizia, A.M. Api
- Year:
- 2 007
- Bibliographic source:
- Food and Chemical Toxicology 45 (2007) S418–S423
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: as mentioned below
- Principles of method if other than guideline:
- An eye irritation study of isoamyl salicylate (CAS No: -87-20-7)was conducted on rabbits.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Isopentyl salicylate
- EC Number:
- 201-730-4
- EC Name:
- Isopentyl salicylate
- Cas Number:
- 87-20-7
- Molecular formula:
- C12H16O3
- IUPAC Name:
- 3-methylbutyl 2-hydroxybenzoate
- Reference substance name:
- isopentyl salicylate (Synonym: isoamyl salicylate)
- IUPAC Name:
- isopentyl salicylate (Synonym: isoamyl salicylate)
- Test material form:
- liquid
- Details on test material:
- Chemical Name: isopentyl salicylate (Synonym: isoamyl salicylate)
Molecular Formula:C12H16O3
Molecular Weight: 208.26 g/mol
Nature of chemical: Organic
Physical State: Liquid
Constituent 1
Constituent 2
- Specific details on test material used for the study:
- Chemical Name: isopentyl salicylate (Synonym: isoamyl salicylate)
Molecular Formula:C12H16O3
Molecular Weight: 208.26 g/mol
Nature of chemical: Organic
Physical State: Liquid
Test animals / tissue source
- Species:
- rabbit
- Strain:
- not specified
- Details on test animals or tissues and environmental conditions:
- No data
Test system
- Vehicle:
- not specified
- Controls:
- not specified
- Amount / concentration applied:
- 15% or 100%
- Duration of treatment / exposure:
- No Data
- Observation period (in vivo):
- No Data
- Number of animals or in vitro replicates:
- Six rabbits
- Details on study design:
- TEST SITE
- Area of exposure: lower eyelids of rabbits
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Score:
- 0
- Remarks on result:
- other: 15% isoamyl salicylate, no irritation observed
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Score:
- 0
- Remarks on result:
- other: 100% isoamyl salicylate, irritation observed in 1 of 6 rabbits
- Irritant / corrosive response data:
- No irritation was observed with 15% isoamyl salicylate when instilled in the lower eyelids of rabbit. Irritation though was observed in 1 rabbit with neat isoamyl salicylate.
- Other effects:
- No data
Any other information on results incl. tables
No irritation was observed with 15% isoamyl salicylate when instilled in the lower eyelids of rabbit. Irritation though was observed in 1 rabbit with neat isoamyl salicylate.
Applicant's summary and conclusion
- Interpretation of results:
- other: not irritating
- Conclusions:
- An eye irritation study of isoamyl salicylate was conducted on rabbits. No irritation was observed with 15% isoamyl salicylate. Irritation though was observed in 1 rabbit with neat isoamyl salicylate. Thus, under the conditions of the test, isoamyl salicylate was not considered to be a primary eye irritant.
- Executive summary:
An eye irritation study of isoamyl salicylate(CAS No: -87-20-7)was conducted on rabbits. 15% and 100% isoamyl salicylate was instilled into the lower eyelids of 6 rabbits. No irritation was observed with 15% isoamyl salicylate. Irritation was observed in 1 rabbit with neat(100%) isoamyl salicylate. Thus, under the conditions of the test, isoamyl salicylate(CAS No: -87-20-7)was not considered to be a primary eye irritant.
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