Registration Dossier
Registration Dossier
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EC number: 279-919-6 | CAS number: 82205-20-7
Endpoint summary
Administrative data
Description of key information
The target substance was tested negative for acute dermal irritating properties in rabbits in a study according to OECD 404. In contrast, the target substance caused severe eye irritating effects in an acute eye irritation/corrosion study in rabbits (OECD 405).
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irreversible damage)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
The target substance was tested negative for acute dermal irritating properties according to OECD 404. The non-irritating properties of the target substance to the skin are supported by a suitable read across partner, which was tested also negative in an in vivo acute dermal irritating study conducted in accordance with OECD 404. In contrast, the target substance was severely irritating to the eyes of rabbits in an acute eye irritation study (OECD 405). Based on these results, the test substance is considered to be not irritating to skin, but severely irritating/corrosive to the eye.
Justification for classification or non-classification
The target substance did not cause any skin effects in acute dermal irritating studies according to OECD test guideline 404. Therefore, the target substance does not warrant classification for skin irritation.
In contrast, the test item was severely irritating to the eyes of rabbits in an OECD 405 study. The application of the substance to the eye of rabbits led to an irreversible effect of the corneal opacity within 21 days observation period. Therefore, the test item meets the classification criteria according to the CLP regulation. The target substance is classified for irreversible effects on the eye (Category 1, H318).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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