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Diss Factsheets

Ecotoxicological information

Toxicity to aquatic algae and cyanobacteria

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Administrative data

Link to relevant study record(s)

Reference
Endpoint:
toxicity to aquatic algae and cyanobacteria
Type of information:
read-across based on grouping of substances (category approach)
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: as reported in source record
Justification for type of information:
see attachment "Read-across justification-environ assessment-iron oxides" and “Endpoint-specific read-across justification for nano forms of iron oxide, 2021” attached in IUCLID section 13.
Reason / purpose for cross-reference:
read-across source
Duration:
72 h
Dose descriptor:
NOEC
Effect conc.:
>= 20 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
growth rate
Remarks on result:
other: as reported in source record
Duration:
72 h
Dose descriptor:
EC50
Effect conc.:
> 20 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
growth rate
Remarks on result:
other: as reported in source record

Description of key information

Applying read-across to nanosizediron(hydr)oxides (see attachment "Read-across justification-environ assessment-iron oxides" and “Endpoint-specific read-across justification for nano forms of iron oxide, 2021” attached in IUCLID section 13), nanosized iron manganese trioxide is not considered toxic to aquatic algae. In a reliable 72-h algae growth inhibition test according to OECD 201 with diiron trioxide nanoparticles, a significant effect on the growth rate of Pseudokirchneriella subcapitata was not observed at concentrations up to 20 mg/L and an unbounded 72 h NOEC >= 20 mg/L was derived (Nogueira et al., 2015).

Key value for chemical safety assessment

Additional information

A 72-h algae growth inhibition test was performedby Nogueira et al. (2015)according to OECD 201 to assess the potential effects of Fe2O3 nanoparticles (average particle size 85 × 425 nm). A significant effect on the growth rate of Pseudokirchneriella subcapitata was not observed at the applied concentrations ranging from 8.2 to 20.0 mg/L. Thus, an unbounded 72-h NOEC of ≥ 20 mg/L (nominal) and 72-h EC50 of > 20 mg/L were derived for the growth inhibition of P. subcapitata.

Based on read-across to nanosized iron (hydr)oxides (see attachment "Read-across justification-environ assessment-iron oxides" and “Endpoint-specific read-across justification for nano forms of iron oxide, 2021” attached in IUCLID section 13), available data indicate a low potential for toxicity ofnanosized iron manganese trioxideto aquatic algae (see table below).

 

Table: Toxicity of nanosized iron (hydr)oxides to aquatic algae.

Endpoint

Test species

Test results

Test material/form

Reliability: Reference

Toxicity to aquatic algae and cyanobacteria

Pseudokirchneriella subcapitata

NOEC (72 h): >= 20 mg/L nominal

EC50 (72 h): > 20 mg/L nominal

diiron trioxide / nano

RL2: Nogueira et al., 2015