Registration Dossier
Registration Dossier
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EC number: 202-616-7 | CAS number: 97-89-2
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Data is from publication
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Monographs on fragrance raw materials
- Author:
- Edited by D.L.J. Opdyke
- Year:
- 1 975
- Bibliographic source:
- Food and Cosmetics Toxicology
- Reference Type:
- other: authoritative database
- Title:
- Acute oral toxicity by using test chemical
- Author:
- U.S. National Library of Medicine
- Year:
- 2 018
- Bibliographic source:
- ChemIDplus
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: As mentioned below
- Principles of method if other than guideline:
- Acute oral toxicity oftest chemical in rat.
- GLP compliance:
- not specified
- Test type:
- other: not specified
- Limit test:
- no
Test material
- Reference substance name:
- Citronellyl propionate
- EC Number:
- 205-461-3
- EC Name:
- Citronellyl propionate
- Cas Number:
- 141-14-0
- Molecular formula:
- C13H24O2
- IUPAC Name:
- 3,7-dimethyloct-6-en-1-yl propanoate
- Details on test material:
- IUPAC name: 3,7-dimethyloct-6-en-1-yl propanoate
Smiles:C([C@@H](CC\C=C(\C)C)C)COC(CC)=O
InChI: 1S/C13H24O2/c1-5-13(14)15-10-9-12(4)8-6-7-11(2)3/h7,12H,5-6,8-10H2,1-4H3
- Name of test material : Citronellyl propionate
- Molecular formula :C13H24O2
- Molecular weight : 212.331 g/mol
- Substance type: Organic
- Physical state: Liquid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- not specified
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
- Details on oral exposure:
- not specified
- Doses:
- >5000 mg/kg bw
- No. of animals per sex per dose:
- not specified
- Control animals:
- not specified
- Details on study design:
- not specified
- Statistics:
- not specified
Results and discussion
- Preliminary study:
- not specified
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other:
- Remarks:
- No mortality observed
- Mortality:
- No mortality observed
- Clinical signs:
- other: not specified
- Gross pathology:
- not specified
- Other findings:
- not specified
Applicant's summary and conclusion
- Interpretation of results:
- other: Not classified
- Conclusions:
- The acute oral LD50 value was considered to be >5000 mg/kg bw rats were treated with test chemical via oral route.
- Executive summary:
Acute oral toxicity study of test chemical was conducted on rats at the dose concentration of >5000 mg/kg bw. All animals were maintained under close observation for recording toxic signs and time of death for 14 days. No mortality observed at the dose of 5000 mg/kg bw. Therefore, LD50 value was considered to be >5000 mg/kg bw, when rats were treated with test chemical via oral route.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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