Registration Dossier
Registration Dossier
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EC number: 203-939-6 | CAS number: 112-14-1
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: data is from peer reviewed journal
Data source
Reference
- Reference Type:
- publication
- Title:
- Fragrance raw materials monographs: Acetate C-8
- Author:
- Bar
- Year:
- 1 974
- Bibliographic source:
- Food and Cosmetics Toxicology. 12, 815, 1974
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: as below
- Principles of method if other than guideline:
- Acute oral toxicity test was conducted in rats
- GLP compliance:
- not specified
- Test type:
- other: No data
- Limit test:
- no
Test material
- Reference substance name:
- Octyl acetate
- EC Number:
- 203-939-6
- EC Name:
- Octyl acetate
- Cas Number:
- 112-14-1
- Molecular formula:
- C10H20O2
- IUPAC Name:
- octyl acetate
- Reference substance name:
- Acetate C-8
- IUPAC Name:
- Acetate C-8
- Test material form:
- other: Liquid
- Details on test material:
- - Name of test material (as cited in study report): Acetate C-8
- Molecular formula (if other than submission substance): C10H20O2
- Molecular weight (if other than submission substance): 172.266 g/mole
- Substance type: Organic
- Physical state: Liquid
Constituent 1
Constituent 2
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- No data available
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
- Details on oral exposure:
- No data available
- Doses:
- 3000 mg/kg
- No. of animals per sex per dose:
- No data available
- Control animals:
- not specified
- Details on study design:
- No data available
- Statistics:
- No data available
Results and discussion
- Preliminary study:
- No data available
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 3 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: 50 % morality was observed
- Mortality:
- 50 % morality was observed in traded rats at 3000 mg/kg
- Clinical signs:
- other: No data available
- Gross pathology:
- No data available
- Other findings:
- No data available
Applicant's summary and conclusion
- Interpretation of results:
- practically nontoxic
- Conclusions:
- LD50 was considered to be 3000 mg/kg when rat were treated with Acetate C-8 orally.
- Executive summary:
In a acute oral toxicity study, rats were treated wtih Acetate C-8 in the contrition of 3000 mg/kg orally. 50 % morality was observed in traded rats at 3000 mg/kg. Therefore, LD50 was considered to be 3000 mg/kg when rat were treated with Acetate C-8 orally.
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