Registration Dossier
Registration Dossier
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EC number: 208-792-1 | CAS number: 541-73-1
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: Relevant methodological deficiencies
Data source
Reference
- Reference Type:
- publication
- Title:
- The bone marrow clastogenicity of eight halogenated benzenes in male NMRI mice
- Author:
- Mohtashamipur E, Triebel R, Straeter H, Norpoth K
- Year:
- 1 987
- Bibliographic source:
- Mutagenesis 2, 111-113 (1987)
Materials and methods
- Principles of method if other than guideline:
- m-dichlorobenzene was tested for acute toxicity (LD50) by intraperitoneal administration
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 1,3-dichlorobenzene
- EC Number:
- 208-792-1
- EC Name:
- 1,3-dichlorobenzene
- Cas Number:
- 541-73-1
- Molecular formula:
- C6H4Cl2
- IUPAC Name:
- 1,3-dichlorobenzene
- Test material form:
- other: liquid
- Details on test material:
- purity: 99.0%
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- NMRI
- Sex:
- male
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- not specified
- Doses:
- no data
- No. of animals per sex per dose:
- no data
- Control animals:
- not specified
Results and discussion
Effect levelsopen allclose all
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 1 061 mg/kg bw
- Based on:
- test mat.
- Dose descriptor:
- other:
- Remarks:
- Study is not reliable (reliability 3) and therefore not relevant for assessment.
Any other information on results incl. tables
no data
Applicant's summary and conclusion
- Executive summary:
m-dichlorobenzene was tested for acute toxicity (LD50) by intraperitoneal administration to NMRI mice. The LD50 was 1061 mg/kg bw.
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