Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 620-315-2 | CAS number: 566-08-5
Partition coefficient
Administrative data
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 019
- Report date:
- 2019
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
- GLP compliance:
- no
- Type of method:
- HPLC method
- Partition coefficient type:
- octanol-water
Test material
- Reference substance name:
- (15α)-15-Hydroxy-androst-4-ene-3,17-dione
- EC Number:
- 620-315-2
- Cas Number:
- 566-08-5
- Molecular formula:
- C19H26O3
- IUPAC Name:
- (15α)-15-Hydroxy-androst-4-ene-3,17-dione
- Test material form:
- solid: particulate/powder
Constituent 1
Study design
- Analytical method:
- high-performance liquid chromatography
Results and discussion
Partition coefficient
- Type:
- log Pow
- Partition coefficient:
- 2
- Temp.:
- 20 °C
- pH:
- 5.92
- Details on results:
- The retention times of the test and reference items were determined in two replicates injecting twice both of them. The test item was dissolved in methanol:deionized water (55:45) and diluted in methanol:deionized water (55:45) to obtain a final concentration of 100 mg/l. Dead-time measured by Thiourea was 0.932 minutes. In order to correlate the calculated capacity factor k of test item with its logPow, a calibration graph using six reference substances were used. The value of partition coefficient of 15α-Hydroxy-androstendione (CAS No. 566-08-5) was determined by Microsoft Office Excel 2013: logPow= 2.0
Applicant's summary and conclusion
- Conclusions:
- The calculated mean logPow of 15α-OH-AD: 2.0
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
