Registration Dossier
Registration Dossier
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EC number: 607-233-2 | CAS number: 2343-89-7
Endpoint summary
Administrative data
Description of key information
Reliable toxicity studies in fish, invertebrates and algae have been conducted for 2-propenoic acid, 2-fluoro, methyl ester and are included in the dossier. The Key studies are summarised below.
A reliable short-term toxicity study with fish is available for 2-propenoic acid, 2-fluoro, methyl ester with a 96-hour LC50 of 6.1 mg/L. Consequently, this value will be taken as the short-term toxicity in fish endpoint for 2-propenoic acid, 2-fluoro, methyl ester.
A reliable short-term toxicity study with invertebrates is available for 2-propenoic acid, 2-fluoro, methyl ester is available with a 48-hour EC50 of 47 mg/L. Consequently, this value will be taken as the short-term toxicity in invertebrates endpoint for 2-propenoic acid, 2-fluoro, methyl ester.
A reliable toxicity study with freshwater algae is available for 2-propenoic acid, 2-fluoro, methyl ester is available with a 72-hour EC50 (growth rate) of 59 mg/L and a 72-hour NOEC (growth rate) of 28 mg/L. Corresponding EC50 and NOEC values relating to biomass (yield) endpoint are also available at 45 mg/L and 28 mg/L, respectively. The OECD test methods preferred endpoint measurements of growth rate will be taken as the toxicity in algae endpoint for 2-propenoic acid, 2-fluoro, methyl ester.
A reliable toxicity study with microorganisms is not available due to the technical feasibility of the test. During preliminary work significant volatilisation of the test substance was incurred after just one hour of aeration.Therefore, it is considered technically justified to waive this study. However, 35% degradation of the test substance was recorded in the OECD 301F biodegradation test indicating that the test substance was not inhibitory to the sewage treatment microorganisms used in the study.
The study requirements for long term toxicity to fish and long term toxicity to aquatic invertebrates are waived in accordance with REACH Annex XI, 3.2.(b). The substance is not incorporated in an article and for all relevant scenarios throughout the life cycle is used under strictly controlled conditions.
Additional information
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