Registration Dossier
Registration Dossier
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EC number: 908-918-1 | CAS number: -
Specific investigations: other studies
Administrative data
- Endpoint:
- specific investigations: other studies
- Remarks:
- sensory irritation measured as respiratory depression
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- Dose-Response analysis in animal studies: Prediction of human responses
- Author:
- Yves Alarie
- Year:
- 1 981
- Bibliographic source:
- Env. Health Persp., Vol. 42, pp. 9-13
Materials and methods
- Principles of method if other than guideline:
- When airborne chemicals impinge on the nasal mucosa, the trigeminal nerve endings are stimulated, and inhibition of respiration occurs with a net result being a decrease in respiratory rate. A correlation exists between this response in animals and the response in humans, i.e., eye, nose, throat irritation.
An RD 50 value was determined, i.e., the concentration leading to a 50% decrease in the respiratory rate. - Type of method:
- in vivo
- Endpoint addressed:
- respiratory irritation
Test material
- Reference substance name:
- Reference substance 001
- Details on test material:
- no data
Constituent 1
Test animals
- Species:
- mouse
Administration / exposure
- Route of administration:
- inhalation: vapour
- Vehicle:
- air
- Frequency of treatment:
- once
Results and discussion
- Details on results:
- RD 50 = 1531 ppm ( 8mg/L)
This is almost in agreement with the graphical data, from which an RD 50 value of 1300 ppm (6.8mg/L) was estimated.
Applicant's summary and conclusion
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