Registration Dossier
Registration Dossier
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EC number: 204-506-4 | CAS number: 121-91-5
Bioaccumulation: aquatic / sediment
Administrative data
Link to relevant study record(s)
Description of key information
The US EPA's KOWWIN model predicts a log Kow of 1.76 for isophthalic acid (IPA, free acid) and the database on which the model is constructed contains a published (public domain) value of 1.66 for IPA (Hansch, C. et al., 1995).
Isophthalate salts are considered to be more environmentally relevant than the parent dicarboxylic acid and these ionised salts are expected to have log Kow values (and bioconcentration potential) lower than that of the parent monomer. This is confirmed by a measured log Kow value of -2.34 obtained for IPA in a system buffered to pH 7 (Hatoum & Garthwaite, 1992).
All these log Kow values lie below the trigger of 3.0 and isophthalic acid is not expected to exhibit significant bioconcentration or bioaccumulation tendencies. According to Column 2 of Annex IX of the REACH regulation studies of bioconcentration/bioaccumulation are therefore not required for IPA.
Key value for chemical safety assessment
Additional information
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