Methacrylic acid, monoester with propane-1,2-diol

Sensitisation data (human)

Administrative data

Endpoint:

sensitisation data (humans)

Type of information:

other: human patch test data collection

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

study well documented, meets generally accepted scientific principles, acceptable for assessment

Remarks:

Bias-positive: patients of dermatologists or dermal clinics are a cohort preselected for having a problem with the skin, so that no valid assessment of actual prevalence can be done.

Data source

Reference

Reference Type:

publication

Title:

Screening for contact allergy to artificial nails

Author:

Constandt L, Hecke EV, Naeyaert JM, Goossens A

Year:

2005

Bibliographic source:

Contact Dermatitis 2005: 52: 7 3-77

Materials and methods

Type of sensitisation studied:

skin

Test material

Test material information

Constituent 1

Reference substance name:

2-hydroxyethyl methacrylate

EC Number:

212-782-2

EC Name:

2-hydroxyethyl methacrylate

Cas Number:

868-77-9

Molecular formula:

C6H10O3

IUPAC Name:

2-hydroxyethyl methacrylate

Specific details on test material used for the study:

2% in pet

Method

Type of population:

occupational

Ethical approval:

not applicable

Subjects:

The population tested comprised 27 patients (26 women and 1 man), all in contact with artificial nails. Of them, 16 were professional beauticians - all had contact with nail tips, gel and/or acrylic nails, glue and nail lacquer. 11 were customers - some had used only gel nails, some only acrylic nails, whereas others had used both types.
A not further specified group of them of 12 patients was tested commercial test series.

Route of administration:

dermal

Details on study design:

12 patients were tested with various substances, 9 with the complete Chemotechnique (Malmö, Sweden) printing series (24 acrylic compounds), 7 with ethyl cyanoacrylate, 5 with a small series of 5 acrylics (MMA, 2-HEMA, EGDMA, BIS-GMA and UEDMA; and 1 with 2-HEMA only.
HEMA was tested at 2% in petrolatum.

Results and discussion

Results of examinations:

In a series of patients known to be exposed to artificial nails 6/11 (> 56%) subjects patch tested with HPMA were positive.

Any other information on results incl. tables

In the same investigations 27/29 tested with HEMA were positive, 4 of 21 tested with methyl methacrylate were positive, and 2 of 13 reacted to ethyl methacrylate.