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EC number: 209-599-5 | CAS number: 587-26-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 28 Dec 2005 - 21 Apr 2006
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP-Guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- Swiss federal office of public health, Bern, Switzerland
- Type of method:
- column elution method
- Water solubility:
- 1.84 mg/L
- Temp.:
- 20 °C
- pH:
- 6.72 - 6.91
- Remarks on result:
- other: Test item Lanthanum carbonate (containing water)
- Water solubility:
- 1.26 mg/L
- Temp.:
- 20 °C
- pH:
- 6.72 - 6.91
- Remarks on result:
- other: Dry test item (value given in the report: 1.12 mg/L; this was a calculation error)
- Details on results:
- The analytical method has been validated in a concentration range from 10 µg/L to 2000 µg/L.
The mean recoveries (triplicate measurements) of the spiked concentrations of 10 µg/L, 100 µg/L and 2000 µg/L were found to be 102.2%, 100.1% and 96.0 %, respectively. - Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 09 Aug - 18 Aug 2010
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP-Guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- GLP compliance:
- yes
- Type of method:
- flask method
- Water solubility:
- 0.8 mg/L
- Temp.:
- 10 °C
- pH:
- 7.9 - 8.1
- Remarks on result:
- other: Replicates of three days, standard deviation: 0.029
- Water solubility:
- 1.24 mg/L
- Temp.:
- 20 °C
- pH:
- 7.7 - 7.9
- Remarks on result:
- other: Replicates of three days, standard deviation: 0.043
- Water solubility:
- 1.81 mg/L
- Temp.:
- 30 °C
- pH:
- 7 - 7.3
- Remarks on result:
- other: Replicates of three days, standard deviation: 0.023
- Details on results:
- Preliminary test:
The water solubility of Dilanthanum tricarbonate was about 2.5 mg/L at 20.0 °C.
Main test:
The difference between the concentrations of the test substance of day 1 to 3 at 10 °C, 20 °C and 30 °C was <15 % and the concentrations of the test substance showed no relevant tendency. Therefore the mean of day 1 - 3 was taken as the solubility of the test substance at all temperatures, according to the guidelines.
As the temperature coefficient of the solubility of the test substance was >3 % (i.e. 3.8 to 4.6 % ) per °C, the solubility was determined at three temperatures, in agreement with the guideline. - Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Study period:
- 23 Mar - 16 Nov 2009
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: GLP-Guideline study, but unsuitable analytical method
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Deviations:
- yes
- Remarks:
- As preliminary study only one flask was prepared: with 10 mg test substance, mixed with 1000 mL deionised water, skahen for 72 h
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Deviations:
- yes
- Remarks:
- As preliminary study only one flask was prepared: with 10 mg test substance, mixed with 1000 mL deionised water, skahen for 72 h
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- Landesamt für Umwelt, Wasserwirtschaft und Gewerbeaufsicht, Kaiser-Friedrich-Straße 7, 55116 Mainz, Germany
- Type of method:
- column elution method
- Water solubility:
- 1.45 µg/L
- Temp.:
- 20 °C
- pH:
- 6.5
- Details on results:
- Water solubility of test item was stated as 1.45 ± 0.28 µg/L.
Standard deviation correlated to a relative standard deviation of 19.3 %.
Variation within the respective flow rates was unobtrusive, but all values showed large variations. The authors stated that this is considered to be due to, firstly, the variation of the analytical method (± 0.2 µg/L), secondly, variation within the samples, and thirdly, measurement uncertainties when determining the volume of the samples resp. adding buffer/Alizarin S.
Following Horwitz (equation: variation = 2^(1 - 0,5 * log c)), a relative standard deviation of 28.7% can be expected when analysing samples with concentrations of 1.45 µg/L. Therefore, the observed standard deviation of 19.3% is considered as uncritical.
Referenceopen allclose all
Results of the water solubility of Lanthanum carbonate:
Experiment No. |
Flow rate (mL/h) |
Sample No. |
Concentra- tion analysed (µg La/L) |
Mean (µg La/L) |
Water solubility calculated * (µg Test item/L) |
Water solubility calculated (mg Test item/L) |
Water solubility calculated (mg Test item/L) |
pH |
1 |
31 |
1.1 1.2 |
780 766 |
773.0 |
1860.230 |
1.83 SD = ± 0.03 Srel = ± 1.57%
|
1.84 SD = ± 0.04 Srel = ± 2.33% |
6.79 |
2.1 2.2 |
768 765 |
766.5 |
1844.588 |
6.85 |
||||
3.1 3.2 |
764 763 |
763.5 |
1837.368 |
6.91 |
||||
4.1 4.2 |
760 760 |
760.0 |
1828.945 |
6.75 |
||||
5.1 5.2 |
740 742 |
741.0 |
1783.222 |
6.87 |
||||
6.1 6.2 |
746 751 |
748.5 |
1801.271 |
6.85 |
||||
2 |
16 |
7.1 7.2 |
760 776 |
768.0 |
1848.198 |
1.86 SD = ± 0.05 Srel = ± 2.76%
|
6.72 |
|
8.1 8.2 |
736 735 |
735.5 |
1769.986 |
6.87 |
||||
9.1 9.2 |
775 772 |
773.5 |
1861.433 |
6.90 |
||||
10.1 10.2 |
785 786 |
785.5 |
1890.311 |
6.82 |
||||
11.1 11.2 |
768 774 |
771.0 |
1855.417 |
6.89 |
||||
12.1 12.2 |
800 798 |
799.0 |
1922.799 |
6.75 |
SD Standard deviation
* calculated with a content of lanthanum = 41.554%
Mass concentration of lanthanum determined at different times of stirring, two solutions used:
Nominal temperature |
Equilibrium time |
pH of the solutions |
Concentration in La (mg/L) |
mean |
Deviation from the max. concentration (%) |
||
1st |
2nd |
1st |
2nd |
||||
10 °C |
1 day |
7.9 |
8.0 |
0.45 |
0.45 |
0.45 |
- 10 |
|
2 day |
8.1 |
8.0 |
0.50 |
0.50 |
0.50 |
0 |
|
3 day |
8.1 |
8.1 |
0.50 |
0.50 |
0.50 |
0 |
|
|
|
|
|
Mean±SD: |
0.48±0.029 |
|
20 °C |
1 day |
7.7 |
7.8 |
0.71 |
0.70 |
0.71 |
-9.6 |
|
2 day |
7.9 |
7.9 |
0.78 |
0.78 |
0.78 |
0 |
|
3 day |
7.8 |
7.9 |
0.78 |
0.78 |
0.78 |
0 |
|
|
|
|
|
Mean±SD: |
0.76±0.043 |
|
30°C |
1 day |
7.1 |
7.2 |
1.07 |
1.07 |
1.07 |
-3.8 |
|
2 day |
7.0 |
7.2 |
1.11 |
1.11 |
1.11 |
0 |
|
3 day |
7.1 |
7.3 |
1.10 |
1.11 |
1.11 |
-0.6 |
|
|
|
|
|
Mean±SD : |
1.10±0.023 |
|
Flow rate 1:
sample |
Interval (min) |
Volume (mL) |
Flow rate (ml/h) |
1-1 |
31 |
12.3 |
23.8 |
1-2 |
27 |
11.6 |
25.8 |
1-3 |
34 |
13.3 |
23.5 |
1-4 |
30 |
12.5 |
25.0 |
1-5 |
28 |
11.8 |
25.3 |
1-6 |
33 |
13.5 |
24.5 |
1-7 |
32 |
12.6 |
23.6 |
mean ± standard deviation |
|
|
24.50 ± 0.921 |
Flow rate 2:
sample |
Interval (min) |
Volume (mL) |
Flow rate (ml/h) |
2-1 |
57 |
11.9 |
12.5 |
2-2 |
46 |
9.4 |
12.3 |
2-3 |
40 |
8.2 |
12.3 |
2-4 |
45 |
9.3 |
12.4 |
2-5 |
45 |
9.4 |
12.5 |
2-6 |
45 |
8.1 |
10.8 |
2-7 |
64 |
13.2 |
12.4 |
mean ±standard deviation |
|
|
12.11 ± 0.649 |
Measurement of La concentration at flow rate 24.6 mL/h
sample |
Measured La concentration (µg/L) |
Calculated Dilanthanum tricarbonate concentration (µg/L] |
Difference to previous sample (%) |
1-1 |
0.65 |
1.07 |
- |
1-2 |
0.75 |
1.24 |
15.48 |
1-3 |
0.83 |
1.37 |
10.71 |
1-4 |
0.88 |
1.46 |
6.26 |
1-5 |
0.94 |
1.55 |
6.29 |
1-6 |
0.98 |
1.62 |
4.44 |
1-7 |
1.11 |
1.84 |
13.67 |
mean |
0.88 |
1.45 |
|
Measurement of La concentration at flow rate 12.11 mL/h
sample |
Measured La concentration (µg/L) |
Calculated Dilanthanum tricarbonate concentration (µg/L] |
Difference to previous sample (%) |
2-1 |
0.71 |
1.17 |
- |
2-2 |
0.65 |
1.07 |
-9.31 |
2-3 |
1.02 |
1.68 |
19.42 |
2-4 |
0.99 |
1.63 |
14.55 |
2-5 |
1.13 |
1.87 |
9.73 |
2-6 |
0.98 |
1.61 |
-17.83 |
2-7 |
0.67 |
1.10 |
-15.39 |
mean |
0.88 |
1.45 |
|
Description of key information
0.80 mg/L at 10°C, 1.24 mg/L at 20 °C, 1.81 mg/L at 30 °C
Key value for chemical safety assessment
- Water solubility:
- 1.24 mg/L
- at the temperature of:
- 20 °C
Additional information
The water solubility of Lanthanum carbonate was investigated with the flask method at three different temperatures according to OECD 105 under GLP conditions (Wenighofer 2010). Due to the water solubility of the test substance determined in the preliminary test, the column elution method should be used for the main test, but this method is not applicable for inorganic substances. In agreement with the guideline, the flask method using a slow stirring technique (< 100 rpm) was chosen. The pH of the solutions were 7.9 to 8.1 at 10 °C, 7.7 to 7.9 °C at 20 °C and 7.0 to 7.3 at 30 °C. The difference between the concentrations of the test substance of day 1 to 3 at 10 °C, 20 °C and 30 °C was < 15% and the concentrations of the test substance showed no relevant tendency. Therefore, the mean of day 1-3 was taken as the solubility of the test substance at all temperatures and the following values were stated: 0.80 mg/L (0.48 mg La/L) with a standard deviation of 0.029 at 10.0 °C, 1.24 mg/L (0.76 mg La/L) with a standard deviation of 0.043 at 20.0 °C and 1.81 mg/L (1.10 mg La/L) with a standard deviation of 0.023 at 30.0 °C.
A further study examined the water solubility with the column elution method also according OECD 105 under GLP-conditions (Weissenfeld 2006). The resulting value for the water solubility was stated as 1.26 mg/L at 20 °C, this is comparable to the value given in the study above.
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