Registration Dossier
Registration Dossier
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EC number: 230-392-0 | CAS number: 7087-68-5
Endpoint summary
Administrative data
Description of key information
The substance is considered as toxic to aquatic organisms and causes long-term adverse effects. (H411)
Additional information
The acute toxicity of Ethyldiisopropylamine (EDIPA) to zebrafish was assessed and no toxicity to fish has been observed during a limit test (mean measured concentration of 69.7 mg/L of EDIPA). In this test, the pH was adjusted because the pH of the solution was very high before adjustment (10.25).
Concerning the algae, the growth inhibition of the freshwater algae Pseudokirchneriella subcapitata was determined. ErC50 and ErC10_72h were determined to be 196 and 118 mg/L, respectively. Similarly to the test with zebrafish, the pH was adjusted to limit the pH increase.
Two toxicity tests to daphnia are available. In the first one, a 48h_EC50 of 28.1 mg/L was estimated with adjustment of pH for the stock solution. In the second one, the 48h_EC50 of EDIPA for daphnia was estimated as 74.3 mg/L with a non-buffered solution and > 100 mg/L when neutralized. Thus the worst result obtained for this trophic level was used as key value i.e. EC50 of 28.1 mg/L.
A long-term toxicity test has been performed on Daphnia magma according to the guidelines OECD 211. A NOEC reproduction of 0.51 mg/L was obtained during this test. With this result, the substance is considered as toxic to aquatic organisms and causes long-term adverse effects (H411).
A long-term toxicity test has been performed on Fathead minnow according to the guidelines OECD 210. No effects were observed until the highest test concentration. A NOEC reproduction of 14 mg/L was obtained during this test.
Finally, the toxicity of EDIPA to bacteria was determined. The result based on the inhibition of the respiration rate was EC50(3h) of 912 mg/L.
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