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EC number: 500-281-4 | CAS number: 98362-33-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1985-11-23 to 1985-12-07
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 985
- Report date:
- 1985
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Version / remarks:
- 1981
- Deviations:
- no
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- 2,3-Epoxypropyl neodecanoate, oligomeric reaction products with toluene-4-sulfonic acid
- EC Number:
- 500-281-4
- EC Name:
- 2,3-Epoxypropyl neodecanoate, oligomeric reaction products with toluene-4-sulfonic acid
- Cas Number:
- 98362-33-5
- Molecular formula:
- Exact identification is not feasible
- IUPAC Name:
- Copolymer of neodecanoic acid oxiranylmethyl ester and 4-methylbenzenesulfonic acid
- Test material form:
- liquid: viscous
- Details on test material:
- Yellowish high viscosity liquid
100%
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- - Strain: Wistar (Bor: WISW (SPF TNO))
- Source: Winkelmann, Borchen (Germany)
- Weight at study initiation: females 153 g, males 206 g (mean)
- Fastening before administration: 16 hours
Environmental conditions: - Feed: R 10 complete feed for rats (Ssniff, Soest; Germany)
- Water: tap water ad libitum
- Room temperature: 20°C (+/- 1°C)
- Humidity: 60% (+/- 5%)
- Air change: 15 times per hour
- Illumination: 12 hour light/dark rhythm
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- The test item was administered undiluted. Rats were fasted for 16 hours and then received a single oral dose by gavage: Volume 9.488 mL/kg bw.
- Doses:
- - Doses: 10000 mg/kg body weight, volume: 9.488 mL/kg bw
- No. of animals per sex per dose:
- 5 males, 5 females
- Control animals:
- no
- Details on study design:
- - Post dose observation period: 14 days
EXAMINATIONS:
- body weight: before and on days 1, 7, 14 after treatment
- clinical signs: up to 6 hours after treatment, then daily
- gross pathology at the end of investigation - Statistics:
- not necessarry
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 10 000 mg/kg bw
- Mortality:
- no mortality
- Clinical signs:
- other: After 1-2 hours some animals had ruffled fur ans one animal diuresis, after 4 hours ruffled fur was observed in 9 animals and diuresis in 10 animals, and later some of them showed staggering gait, slight ataxia and sedation, diarrhoe and a squatting posi
- Gross pathology:
- Dissection at the end of the experiment revealed hyperaemia of the gastric mucosa in 5 animals and additionally in one animal partial hyperaemia of the small intestinal mucosa
- Other findings:
- no further information
Any other information on results incl. tables
no further remarks
Applicant's summary and conclusion
- Conclusions:
- Under the conditions of this study, the acute toxicity of the test item in male and female rats is greater than 10000 mg/kg body weight.
- Executive summary:
In a determination of the acute oral toxicity in a limit test of 2,3-Epoxypropyl neodecanoate, oligomeric reaction products with toluene-4-sulfonic acid
5 male and 5 female rats received a single oral dose by gavage of 10000 mg/kg body weight. After 1-2 hours some animals had ruffled fur and one animal diuresis, after 4 hours ruffled fur was observed in 9 animals and diuresis in 10 animals, and later some of them showed staggering gait, slight ataxia and sedation, diarrhoe and a squatting position.While after 24 hours diuresis was still observed in 9 animals, all of them were free from the symptoms of poisoning after 48 hours. The increase of body weight was unaffected by the treatment. Dissection at the end of the experiment revealed hyperaemia of the gastric mucosa in 5 animals and additionally in one animal partial hyperaemia of the small intestinal mucosa
Under the conditions of this study, the acute toxicity of 2,3-Epoxypropyl neodecanoate, oligomeric reaction products with toluene-4-sulfonic acid in male and female rats is greater than 10000 mg/kg body weight.
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