Registration Dossier
Registration Dossier
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EC number: 293-426-3 | CAS number: 91079-38-8
Biodegradation in water: screening tests
Administrative data
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
- Justification for type of information:
- See attached QPRF and QMRF documents.
Data source
Referenceopen allclose all
- Reference Type:
- other: Estimation software
- Title:
- Estimation Programs Interface Suite for Microsoft Windows, v4.11
- Author:
- US EPA
- Year:
- 2 012
- Bibliographic source:
- United States Environmental Protection Agency, Washington DC, USA; November 2012
- Reference Type:
- publication
- Title:
- Group contribution method for predicting probability and rate of aerobic biodegradation.
- Author:
- Boethling, R.S., Howard, P.H., Meylan, W., Stiteler, W., Beaumann, J., Tirado, N.
- Year:
- 1 994
- Bibliographic source:
- Environ. Sci. Technol. 28:459-65.
- Reference Type:
- publication
- Title:
- Predicting Ready Biodegradability of Premanufacture Notice Chemicals.
- Author:
- Boethling, R.S., Lynch. D.G., Thom, G.C.
- Year:
- 2 003
- Bibliographic source:
- Environ. Toxicol. Chem. 22:837-844.
- Reference Type:
- publication
- Title:
- BIOWIN v4.10 (September 2010)
- Author:
- US EPA
- Year:
- 2 010
- Bibliographic source:
- United States Environmental Protection Agency, Washington, DC, USA.
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: REACH guidance on information requirements and chemical safety assessment, chapter R.6: QSARs and grouping of chemicals.
- Version / remarks:
- May 2008
- Principles of method if other than guideline:
- (Q)SAR calculation: EPIWEB V4.1 - Biowin V 4.10
- GLP compliance:
- no
Test material
- Reference substance name:
- Peptones, beef
- EC Number:
- 293-426-3
- EC Name:
- Peptones, beef
- Cas Number:
- 91079-38-8
- Molecular formula:
- The substance is an UVCB. The molecular formula as well as the molecular weight are not defined.
- IUPAC Name:
- Peptones, beef
- Test material form:
- solid: particulate/powder
Constituent 1
- Specific details on test material used for the study:
- L-arginine (CAS# 74-79-3): NC(CCCNC(N)=N)C(O)=O
Glycine (CAS# 56-40-6): NCC(O)=O
Alanine (CAS# 302-72-7): C[C@H](N)C(O)=O
Phenlalaine (CAS# 63-91-2): N[C@@H](CC1=CC=CC=C1)C(O)=O
Trytophan (CAS# 73-22-3): N[C@@H](CC1=CNC2=C1C=CC=C2)C(O)=O
Results and discussion
% Degradationopen allclose all
- Parameter:
- probability of ready biodegradability (QSAR/QSPR)
- Remarks:
- yes
- Remarks on result:
- readily biodegradable based on QSAR/QSPR prediction
- Remarks:
- CAS# 73-22-3
- Parameter:
- probability of ready biodegradability (QSAR/QSPR)
- Remarks:
- yes
- Remarks on result:
- readily biodegradable based on QSAR/QSPR prediction
- Remarks:
- CAS# 56-40-6
- Parameter:
- probability of ready biodegradability (QSAR/QSPR)
- Remarks:
- yes
- Remarks on result:
- readily biodegradable based on QSAR/QSPR prediction
- Remarks:
- CAS# 302-72-7
- Parameter:
- probability of ready biodegradability (QSAR/QSPR)
- Remarks:
- yes
- Remarks on result:
- readily biodegradable based on QSAR/QSPR prediction
- Remarks:
- CAS# 63-91-2
- Parameter:
- probability of ready biodegradability (QSAR/QSPR)
- Remarks:
- yes
- Remarks on result:
- readily biodegradable based on QSAR/QSPR prediction
- Remarks:
- CAS# 74-79-3
- Details on results:
- See attached QSPR for individual BioWin results.
Applicant's summary and conclusion
- Validity criteria fulfilled:
- not applicable
- Interpretation of results:
- readily biodegradable
- Conclusions:
- Peptone, beef is registered as a UVCB as its composition can vary a lot depending on the manufacture process, although amino acids are the majority constituent(s). The biodegradation obtained from BIOWIN v4.10 QSAR model for several amino acids are concluded as biodegradable; therefore peptones, beef should be considered biodegradable.
- Executive summary:
Peptone, beef is registered as a UVCB as its composition can vary a lot depending on the manufacture process, although amino acids are the majority constituent(s). The biodegradation obtained from BIOWIN v4.10 QSAR model for several amino acids are concluded as biodegradable; therefore Peptones, beef should be considered biodegradable.
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