Registration Dossier
Registration Dossier
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EC number: 271-208-9 | CAS number: 68526-52-3
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
There were no skin sensitisation study identified for alkenes, C6. Therefore, a read-across skin sensitisation study was identified, in which SHOP C68 was administered to 20 test and 10 control Dunkin-Hartley guinea pigs (Rees, 1996). The following doses were selected based on a range-finding experiment: 50% in paraffin oil for the intradermal induction; 100% for the topical induction; and 100% and 30% in paraffin oil for the challenge phase. During the challenge phase, 16 test animals and 4 control animals exhibited a positive response to 100% SHOP C68. At 30% SHOP C68, 5 test animals and no control animals exhibited a positive response. Only one test animal showed a positive response to paraffin oil alone during the challenge phase.
Based on these responses, a re-challenge was conducted with 50% SHOP C68. Two test animals and 1 control test animals exhibited a positive response. Again, one test animal showed a positive response to paraffin oil during the challenge phase. Based on these results, SHOP C68 was not determined to be a skin sensitiser.
Migrated from Short description of key information:
A read-across skin sensitisation study (OECD 406) was identified from alkenes, C6-8 that showed no evidence of sensitisation in guinea pigs. Alkenes, C6 are not dermal sensitisers and contain no chemical alerts for respiratory sensitisation.
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
Not expected to cause respiratory sensitisation based on results of skin sensitisation testing and an absence of reactive chemical alerts.
Migrated from Short description of key information:
Not expected to cause respiratory sensitisation based on results of skin sensitisation testing and an absence of reactive chemical alerts.
Justification for classification or non-classification
Negative results from a skin sensitisation study with alkenes, C6-8 (structural analogues) were read-across to alkenes C6. It was therefore inferred that alkenes, C6 would also not be a skin sensitizer. Therefore, alkenes, C6 do not meet the criteria for classification as a dermal sensitizer under EU Dangerous Substances Directive 67/548/EEC or CLP EU Regulation 1272/2008.
There are no data available for respiratory sensitisation for isomerised olefins; alpha, internal, linear and branched – multiple carbon number including alkenes, C6. However, alkenes, C6 are not expected to cause respiratory sensitisation based on results of skin sensitisation and an absence of reactive chemical alerts.
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