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Diss Factsheets

Administrative data

Key value for chemical safety assessment

Genetic toxicity in vitro

Description of key information
The following data are availble for the genetic toxicity endpoint: - experimental Ames tests (pubblished data) - Ames test by QSAR (Toxboxes) - Chromosomal aberration by QSAR (Derek)
Link to relevant study records
Reference
Endpoint:
in vitro gene mutation study in bacteria
Remarks:
Type of genotoxicity: gene mutation
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Principles of method if other than guideline:
Guideline not reported.
GLP compliance:
not specified
Type of assay:
bacterial reverse mutation assay
Species / strain / cell type:
S. typhimurium TA 98
Species / strain / cell type:
S. typhimurium TA 100
Metabolic activation:
with and without
Test concentrations with justification for top dose:
1-10 UMOL/PLATE
Species / strain:
S. typhimurium, other: TA98, TA100
Metabolic activation:
with and without
Genotoxicity:
negative
Cytotoxicity / choice of top concentrations:
not specified
Conclusions:
Interpretation of results (migrated information):
negative
Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (negative)

Additional information

Additional information from genetic toxicity in vitro:

Toxboxes shown an alert for the Ames test.

The experimental data found in literature shown a negative result.

The chromosomal aberration (QSAR by Derek) shown no alerts.

Justification for classification or non-classification

The experimental data available in literature are judged more reliabile of the predicted data by Toxboxes. In addition the QSAR on chromosomal aberration shown no alerts.