6-chloro-1,3-dihydroindol-2-one

Guidance on Safe Use

First-aid measures

Description of First Aid Measures

Eye Contact: Immediately flush eyes with water for at least 15 minutes. If irritation occurs or persists, get medical attention.

Skin Contact: Remove clothing and wash affected skin with soap and water. If irritation occurs or persists, get medical attention. This material may not be completely removed by conventional laundering. Consult professional laundry service. Do not home launder.

Ingestion: Get medical attention immediately. Do not induce vomiting unless directed by medical personnel. Never give anything by mouth to an unconscious person.

Inhalation: Remove to fresh air. If not breathing, give artificial respiration. Get medical attention.

Most Important Symptoms and Effects, Both Acute and Delayed

Symptoms and Effects of Exposure: No data available

Medical Conditions Aggravated by Exposure: None known

Indication of the Immediate Medical Attention and Special Treatment Needed

Notes to Physician: None

Fire-fighting measures

Extinguishing Media: Use carbon dioxide, dry chemical, or water spray.

Special Hazards Arising from the Substance or Mixture

Hazardous Combustion Products: May emit toxic fumes of carbon monoxide, carbon dioxide, nitrogen oxides, hydrogen chloride, and other chlorine-containing compounds.

Fire / Explosion Hazards: High sensitivity of a dust cloud to ignition, based on minimum ignition energy.

Advice for Fire-Fighters

Wear approved positive pressure, self-contained breathing apparatus and full protective turn out gear.

Accidental release measures

Personal Precautions, Protective Equipment and Emergency Procedures

Personnel involved in clean-up should wear appropriate personal protective equipment. Minimize exposure.

Eliminate all sources of ignition and ventilate area using explosion-proof equipment.

Environmental Precautions

Place waste in an appropriately labeled, sealed container for disposal. Care should be taken to avoid environmental release.

Methods and Material for Containment and Cleaning Up

Measures for Cleaning / Collecting: Contain the source of spill if it is safe to do so. Collect spill with absorbent material. Clean spill area thoroughly. Collect spilled material by a method that controls dust generation. Wipe up with a damp cloth and place in container for disposal.

Additional Consideration for Large Spills: Non-essential personnel should be evacuated from affected area. Report emergency situations immediately. Clean up operations should only be undertaken by trained personnel.

Handling and storage

Precautions for Safe Handling

Eliminate possible ignition sources (e.g., heat, sparks, flame, impact, friction, electricity), and follow appropriate grounding and bonding procedures. Avoid contact with eyes, skin and clothing. Avoid breathing dust. Minimize dust generation and accumulation. Use with adequate ventilation. All conductive elements of the system that contact the dry substance should be properly bonded and grounded and equipped with proper explosion relief or suppression systems. This material should not be flowed through nonconductive ducts or pipes because of the potential for electrostatic discharge ignition. Restricting the use of high resistivity materials, such as plastics, should be considered. Ground and bond all bulk transfer equipment. Avoid open handling. Minimize dust generation. Use local exhaust ventilation or perform work under fume hood/fume cupboard. Avoid inhalation and contact with skin, eye, and clothing. When handling, use appropriate personal protective equipment. Wash hands and any exposed skin after removal of PPE. Releases to the environment should be avoided. Review and

implement appropriate technical and procedural waste water and waste disposal measures to prevent occupational exposure or environmental releases. Potential points of process emissions of this material to the atmosphere should be controlled with dust collectors, HEPA filtration systems or other equivalent controls.

Conditions for Safe Storage, Including any Incompatibilities

Storage Conditions: Keep in tightly sealed containers in a well-ventilated area away from heat and sources of ignition.

Specific end use(s): No data available

Transport information

Land transport (UN RTDG/ADR/RID)

UN number:

UN 3077

Shipping information

Proper shipping name and description:

Environmentally Hazardous Substance, Solid, n.o.s (6-Chloro-1,3-dihydro-2H-indol-2-one; [6-chlorooxindole])

SpecialProvisions

Inland waterway transport (UN RTDG/ADN(R))

UN number:

UN 3077

Shipping information

Proper shipping name and description:

Environmentally Hazardous Substance, Solid, n.o.s (6-Chloro-1,3-dihydro-2H-indol-2-one; [6-chlorooxindole])

Remarks

Marine transport (UN RTDG/IMDG)

UN number:

UN 3077

Shipping information

Proper shipping name and description:

Environmentally Hazardous Substance, Solid, n.o.s (6-Chloro-1,3-dihydro-2H-indol-2-one; [6-chlorooxindole])

Marine pollutant

Remarks

Air transport (UN RTDG/ICAO/IATA)

UN number:

UN 3077

Shipping information

Proper shipping name and description:

Environmentally Hazardous Substance, Solid, n.o.s (6-Chloro-1,3-dihydro-2H-indol-2-one; [6-chlorooxindole])

Remarks

Additional transport information

Additional information

Special provisions / remarks / other:

This material is regulated for transportation as a hazardous material/dangerous good.

Exposure controls / personal protection

Control Parameters

Pfizer OEL TWA-8 Hr: 700 μg/m3, Sensitizer

Analytical Method: Analytical method available. Contact Pfizer Inc for further information.

Exposure Controls

Engineering Controls: Engineering controls should be used as the primary means to control exposures. Use process containment, local exhaust ventilation, or other engineering controls to maintain airborne levels below recommended exposure limits.

Personal Protective Equipment:

Refer to applicable national standards and regulations in the selection and use of personal protective equipment (PPE).

Hands: Wear impervious gloves to prevent skin contact.

Eyes: Wear safety glasses as minimum protection.

Skin: Wear impervious protective clothing to prevent skin contact - consider use of disposable clothing where appropriate.

Respiratory protection: If the applicable Occupational Exposure Limit (OEL) is exceeded, wear an appropriate respirator with a protection factor sufficient to control exposures to below the OEL.

Stability and reactivity

Reactivity: No data available

Chemical Stability: Thermally stable at 75°C for 48 hours.

Possibility of Hazardous Reactions

Oxidizing Properties: Non-oxidizing

Conditions to Avoid: Keep away from heat and other sources of ignition, including electrostatic discharge.

Incompatible Materials: As a precautionary measure, keep away from strong oxidizers

Hazardous Decomposition Products: No data available

Disposal considerations

Waste Treatment Methods: Dispose of waste in accordance with all applicable laws and regulations. Member State specific and Community specific provisions must be considered. Considering the relevant known environmental and human health hazards of the material, review and implement appropriate technical and procedural waste water and waste disposal measures to prevent occupational exposure and environmental release. It is recommended that waste minimization be practiced. The best available technology should be utilized to prevent environmental releases. This may include destructive techniques for waste and wastewater.