Registration Dossier
Registration Dossier
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EC number: 233-036-2 | CAS number: 10025-67-9
Toxicological Summary
Administrative data
Workers - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- hazard unknown (no further information necessary)
- Most sensitive endpoint:
- irritation (respiratory tract)
Acute/short term exposure
- Hazard assessment conclusion:
- hazard unknown (no further information necessary)
- Most sensitive endpoint:
- irritation (respiratory tract)
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- high hazard (no threshold derived)
- Most sensitive endpoint:
- irritation (respiratory tract)
Acute/short term exposure
- Hazard assessment conclusion:
- high hazard (no threshold derived)
- Most sensitive endpoint:
- irritation (respiratory tract)
DNEL related information
Workers - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- hazard unknown (no further information necessary)
- Most sensitive endpoint:
- skin irritation/corrosion
Acute/short term exposure
- Hazard assessment conclusion:
- hazard unknown (no further information necessary)
- Most sensitive endpoint:
- skin irritation/corrosion
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- high hazard (no threshold derived)
- Most sensitive endpoint:
- skin irritation/corrosion
Acute/short term exposure
- Hazard assessment conclusion:
- high hazard (no threshold derived)
- Most sensitive endpoint:
- skin irritation/corrosion
Workers - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- high hazard (no threshold derived)
Additional information - workers
No repeated dose studies for the derivation of DNELs are available or planned due to exposure considerations:
According to REACH Annex XI section 3.2 (b) and (c), testing is omitted, based on the scenarios developed in the CSR. In scenarios describing the substance not being incorporated in an article it could be demonstrated that strictly controlled conditions as set out in Article 18.4. (a)-(f) apply throughout the life-cycle of the substance. Furthermore it was demonstrated that the substance is not released from articles based on the use of the substance as a monomer and that exposure to workers, to the general public and to the environment is negligible under normal or reasonable foreseeable conditions.
Local effects:
According to ECHA Guidance on information requirements and chemical safety assessment Part E: Risk characterisation, disulphur dichloride (S2Cl2) should be allocated to the high hazard band due to classification as a corrosive compound; R35.
Potential systemic effects are unlikely:
S2Cl2 is rapidly (t 1/2 < 2 minutes) and quantitatively (97.7 - 101.7 %) hydrolysed in water at 23 °C and pH ranging from 4 to 9 in a guideline hydrolysis study. The hydrolysis products are HCl and different sulphur containing molecules in varying amounts including sulphite, sulphate, thiosulphate, sulphide and precipitable sulphur.
Based on the toxicokenetic considerations in IUCLID chapter 7.1 systemic toxicity of the hydrolysis products is low, as the hydrolysis products are endogenously occurring substances. Due to the corrosive nature of S2Cl2 no significant exposure is assumed (high hazard band); and it can be assumed that that no hydrolysis product is present at biologically relevant doses after exposure to S2Cl2. At concentrations not exceeding the buffer capacity of body fluids, the free acids resulting from the hydrolysis of S2Cl2 will be neutralized quickly by body fluids and do not pose a systemic risk to human health.
General Population - Hazard via inhalation route
Systemic effects
Acute/short term exposure
DNEL related information
Local effects
Acute/short term exposure
DNEL related information
General Population - Hazard via dermal route
Systemic effects
Acute/short term exposure
DNEL related information
General Population - Hazard via oral route
Systemic effects
Acute/short term exposure
DNEL related information
General Population - Hazard for the eyes
Additional information - General Population
Since exposure for the general public, via inhalation, the oral or dermal route and long-term exposure in general are not given, the corresponding DNELs are not derived.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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