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Physical & Chemical properties

Water solubility

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Administrative data

Link to relevant study record(s)

Reference
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
29.07.2010 - 22.11.2010
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
EU Method A.6 (Water Solubility)
Deviations:
no
Qualifier:
according to guideline
Guideline:
OECD Guideline 105 (Water Solubility)
Deviations:
no
Principles of method if other than guideline:
Due to the high water solubility of the test substance and the already attained precision the water solubility was only estimated visually and not determined by the full flask method. The experimental estimation was performed with solutions of the test substance in water between 200 g/L and 943 g/L. The "solutions" were checked visually for undissolved particles.
GLP compliance:
yes
Type of method:
other: Estimation (visually)
Key result
Water solubility:
> 943 g/L
Conc. based on:
test mat.
Temp.:
20 °C
pH:
>= 2.4 - <= 2.5

Results

The test temperature was 20 °C. The water solubility of the test item was estimated to be >943 g/L at 20 °C.

mass of the test substance

Filled up with water to

concentration

pH

annotations

(g)

(mL)

(g/L)

1.00

5.0

200

--

 

clear liquid

2.92

3.3

884

2.5

5.00

5.3

943

2.4
Conclusions:
The water solubility of the test substance was estimated to be >943 g/L at 20 °C.
Executive summary:

The water solubility of the test item was determined in a study performed according to OECD 105 and Regulation (EC) No 440/2008 Method A.6. A solubility preliminary test was perfomed first. The investigations were performed at 20.0 °C with solutions of the test substance in water between 200 g/L and 943 g/L. After fitting with stoppers the flasks were placed in a water bath where the solutions were shaken in intervals. One hour after starting the investigation the solutions were checked visually for undissolved particles. In all three flasks the test item was dissolved and clear liquid was observed. The water solubility of the test substance was estimated to be >943 g/L at 20 °C. Due to the high water solubility of the test substance and the already attained precision the water solubility was only determined in a preliminary experiment and not by the full flask method.

Description of key information

The water solubility of the test substance was estimated to be >943 g/L at 20 °C (reference 4.8-1).

Key value for chemical safety assessment

Additional information

The water solubility of the test item was determined in a study performed according to OECD 105 and Regulation (EC) No 440/2008 Method A.6. A solubility preliminary test was perfomed first.The investigations were performed at 20.0 °C with solutions of the test substance in water between 200 g/L and 943 g/L. After fitting with stoppers the flasks were placed in a water bath where the solutions were shaken in intervals. One hour after starting the investigation the solutions were checked visually for undissolved particles. In all three flasks the test item was dissolved and clear liquid was observed.The water solubility of the test substance was estimated to be >943 g/L at 20 °C. Due to the high water solubility of the test substance and the already attained precision the water solubility was only determined in a preliminary experiment and not by the full flask method.