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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

(2 -Bromoethyl)benzene is not irritant to skin.

Key value for chemical safety assessment

Skin irritation / corrosion

Link to relevant study records
Reference
Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
weight of evidence
Study period:
1995
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
This information is taken from a reliable peer reviewed pulication.
Qualifier:
no guideline available
Principles of method if other than guideline:
The use of secondary sources of data is acceptable when they are based on a critcal evaluation of peer-reviewed data and a sonsequent slection of a reliable and representative value for the property under investigation. Therefore, although the method used is not known, the value presented here are acceptable as they are from a reliable secondary source of toxiicologies.
GLP compliance:
not specified
Specific details on test material used for the study:
purity 99.5 %
Product No. B6,578-0
Supplier ALdrich
Species:
rabbit
Strain:
not specified
Controls:
not specified
Amount / concentration applied:
0.5 ml/ 100%
Duration of treatment / exposure:
4 hours
Observation period:
1h, 1d, 2d and 3d
Number of animals:
3
Details on study design:
Not available
Irritation parameter:
erythema score
Basis:
animal #1
Time point:
other: 1h
Score:
0
Irritation parameter:
erythema score
Basis:
animal #2
Time point:
other: 1h
Score:
0
Irritation parameter:
erythema score
Basis:
animal #3
Time point:
other: 1h
Score:
0
Irritation parameter:
erythema score
Basis:
animal #1
Time point:
24/48/72 h
Score:
0
Irritation parameter:
erythema score
Basis:
animal #2
Time point:
24/48/72 h
Score:
0
Irritation parameter:
erythema score
Basis:
animal #3
Time point:
24/48/72 h
Score:
0
Irritation parameter:
edema score
Basis:
animal #1
Time point:
other: 1h
Score:
0
Irritation parameter:
edema score
Basis:
animal #2
Time point:
other: 1h
Score:
0
Irritation parameter:
edema score
Basis:
animal #3
Time point:
other: 1h
Score:
0
Irritation parameter:
edema score
Basis:
animal #1
Time point:
24/48/72 h
Score:
0
Irritation parameter:
edema score
Basis:
animal #2
Time point:
24/48/72 h
Score:
0
Irritation parameter:
edema score
Basis:
animal #3
Time point:
24/48/72 h
Score:
0
Irritant / corrosive response data:
Primary Irritation Index = 0
Primary Irritaion idex is defined as follow;
Primary irritation index = (sum erythema 24/48/72 hr + sum edema 24/48/72hr)/(3 x no of animals)
Interpretation of results:
GHS criteria not met
Conclusions:
(2-Bromoethyl)benzene is not irritant to skin within this experiment.
Executive summary:

(2-Bromoethyl)benzene is not irritant to skin within this experiment.

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not irritating)

Additional information

Justification for classification or non-classification