Iodine pentafluoride

Skin irritation / corrosion

Administrative data

Endpoint:

skin irritation: in vivo

Type of information:

experimental study

Adequacy of study:

supporting study

Reliability:

4 (not assignable)

Rationale for reliability incl. deficiencies:

other: Published study, acceptable with restrictions (only a brief summary of methods and results was published).

Data source

Reference

Reference Type:

publication

Title:

The comparative skin irritant properties of dichlorethylsulphide ("mustard gas") and other agents

Author:

Hanzlik P.J. and Tarr J.

Year:

1919

Bibliographic source:

J. Pharm. Exp. Therap., 1919, Vol. XIV, no. 3, pp 221-228

Materials and methods

Test guideline

Qualifier:

no guideline available

Principles of method if other than guideline:

The study predates OECD/EU/EPA test guidelines. The publication does not present substance specific information. Compounds were applied to animal (non-rodent, mostly dog) or human skin, by direct application, diluted in a suitable solvent or by a vapour method. Time of appearance of hyperemia and other changes was noted and the extension and severity of all changes was studied quantitatively (results were expressed in terms of square centimetres of area involved). No data are given on the duration of the exposure and observation periods.

GLP compliance:

no

Remarks:

Study predated GLP guidelines

Test material

Test material information

Constituent 1

Reference substance name:

Iodine pentafluoride

EC Number:

232-019-7

EC Name:

Iodine pentafluoride

Cas Number:

7783-66-6

Molecular formula:

F5I

IUPAC Name:

pentafluoro-λ⁵-iodane

Test material form:

solid: particulate/powder

Remarks:

migrated information: powder

Details on test material:

- Name of test material (as cited in study report): iodine pentafluoride

Test animals

Species:

other: non-rodent

Details on test animals or test system and environmental conditions:

The publication does not indicate on which animal species the substance was tested. The following general information is given: Dogs were used principally owing to the limited amount of human material and the large number of compounds studied. Human skin was used as much as permissible and possible. Monkeys, a horse and the cock's comb and wattles were also used. Rodents were not used.

Test system

Type of coverage:

open

Preparation of test site:

other: Animals: shaving and washing. Humans: no data.

Vehicle:

unchanged (no vehicle)

Remarks:

Compounds were also tested as dilutions in a suitable solvent but no substance-specific information is given.

Controls:

not specified

Amount / concentration applied:

The publication does not present substance specific information. The following general information is given:
- Amount applied to animal skin (5 cm2 area): 0.005 cc. (from a pipette graduated to deliver 0.005 to 0.05 cc.) or 5 mg of the compound equivalent to the application of 0.001 cc. (or 1 mg) per cm2 of skin.
- On human skin the tests were made by touching a small area with a fine glass rod dipped into the irritant. This method could not be used quantitatively.
- Vapours of volatile compounds were tested by two qualitative methods (vapor concentration not known) and a quantitative method (with determined vapor concentration).

Observation period:

The time of appearance of hyperemia and all other changes was noted, and the extension and severity of all changes was studied quantitatively as much as possible from day to day and the results expressed in terms of square centimeters of area involved. Dichlorethylsulphide was chosen as the standard by which the irritant properties of other compounds were judged.

Results and discussion

In vivo

Results

Remarks on result:

other: Iodine pentafluoride was found to be a severe irritant as indicated by hyperemia, swelling and edema, ulceration, necrosis, etc., on dog's skin and similar changes together with vesication on human skin.

Irritant / corrosive response data:

Iodine pentafluoride was found to be a severe irritant as indicated by hyperemia, swelling and edema, ulceration, necrosis, etc., on dog's skin and similar changes together with vesication on human skin.

Applicant's summary and conclusion

Conclusions:

Iodine pentafluoride was found to be a severe irritant in an in vivo study predating OECD and GLP guidelines.

Executive summary:

The skin irritant properties of various compounds were tested in vivo in studies predating OECD and GLP guidelines. The available publication does not present substance specific information, only a brief summary of methods and results was published. The compounds were applied to animal (non-rodent, mostly dog) or human skin, by direct application, diluted in a suitable solvent or by a vapor method. Time of appearance of hyperemia and other changes was noted and the extension and severity of all changes was studied quantitatively (results were expresseed in terms of square centimeters of area involved). No data are given on the duration of the exposure and observation periods. Iodine pentafluoride was found to be a severe irritant as indicated by hyperemia, swelling and edema, ulceration, necrosis, etc., on dog's skin and similar changes together with vesication on human skin.