Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
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EC number: 297-474-6 | CAS number: 93572-43-1 A complex combination of hydrocarbons obtained by refining of crude oil. It consists predominantly of aromatics, naphthenics and paraffinics and produces a finished oil with a viscosity of 120 SUS at 100°F (23cSt at 40°C).
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (non-LLNA)
- Type of information:
- migrated information: read-across based on grouping of substances (category approach)
- Adequacy of study:
- key study
- Study period:
- 1986
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study summary report
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- ROBUST SUMMARY OF INFORMATION ON LUBRICATING OIL BASESTOCKS
- Author:
- American Petroleum Institute
- Year:
- 2 003
- Bibliographic source:
- ROBUST SUMMARY OF INFORMATION ON LUBRICATING OIL BASESTOCKS pag 35-36
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 406 (Skin Sensitisation)
- Deviations:
- not specified
- GLP compliance:
- not specified
- Type of study:
- Buehler test
Test material
- Reference substance name:
- Distillates (petroleum), hydrotreated light naphthenic
- EC Number:
- 265-156-6
- EC Name:
- Distillates (petroleum), hydrotreated light naphthenic
- Cas Number:
- 64742-53-6
- IUPAC Name:
- 64742-53-6
Constituent 1
In vivo test system
Test animals
- Species:
- guinea pig
- Strain:
- not specified
- Sex:
- male/female
Study design: in vivo (non-LLNA)
Inductionopen allclose all
- Route:
- epicutaneous, occlusive
- Vehicle:
- paraffin oil
- Concentration / amount:
- 1st: Induction 50 % occlusive epicutaneous
2nd: Challenge 1 % occlusive epicutaneous
3rd:
Challengeopen allclose all
- Route:
- epicutaneous, occlusive
- Vehicle:
- paraffin oil
- Concentration / amount:
- 1st: Induction 50 % occlusive epicutaneous
2nd: Challenge 1 % occlusive epicutaneous
3rd:
- No. of animals per dose:
- 10
Results and discussion
In vivo (non-LLNA)
Results
- Reading:
- other: The results are explained in Any other information on results
- Remarks on result:
- other: Reading: other: The results are explained in Any other information on results.
Any other information on results incl. tables
The criteria used to evaluate the responses are described in the report as follows: Determination of sensitization was based upon reactions to the challenge dose. Grades of 1 or greater in the test animals indicate evidence of sensitization, provided grades of less than 1 are seen in the naive controls. If grades of 1 or greater are noted in the naive control animals, then the reactions of test animals that exceed the most severe naive control reaction are considered sensitization reactions.
One animal had a score of 0.5 after challenge with test substance. In contrast, all the positive control animals were sensitized by their treatment. The sample of test substance was therefore non sensitizing.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
