Registration Dossier
Registration Dossier
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EC number: 271-898-1 | CAS number: 68611-64-3
Partition coefficient
Administrative data
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2008-06-25 - 2008-07-08
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: The GLP study was conducted according to an internationally accepted guideline. All study parameters are based on the specific guideline.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 008
- Report date:
- 2008
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- HPLC method
- Partition coefficient type:
- octanol-water
Test material
- Reference substance name:
- Urea, reaction products with formaldehyde
- EC Number:
- 271-898-1
- EC Name:
- Urea, reaction products with formaldehyde
- Cas Number:
- 68611-64-3
- Molecular formula:
- not available
- IUPAC Name:
- Urea, reaction products with formaldehyde
- Test material form:
- other: liquid
Constituent 1
Study design
- Analytical method:
- high-performance liquid chromatography
Results and discussion
Partition coefficient
- Type:
- log Pow
- Partition coefficient:
- < 0
- Temp.:
- 20 °C
- pH:
- 7
Applicant's summary and conclusion
- Conclusions:
- The partition coefficient of the test substance (Weikoform) was determined. The procedure was performed according to EU Method A.8, Partition coefficient, Directive 92/69/EEC, published in OJ No L 383 A, 1992. With respect to the character of the test substance (a mixture of compounds) and to the results of QSAR estimations of Log Pow of main components it was concluded that the partition coefficient of Weikoform could be evaluated only by means of a calculation method. The partition coefficients of all main components of the test substance were calculated. For the confirmation of calculated values of the partition coefficients, an HPLC experiment was performed, the results of which were in accordance with calculation (except for Methenamin, where HPLC method is still inapplicable).
- Executive summary:
The partition coefficient of the test substance (Weikoform) was determined. The procedure was performed according to EU Method A.8, Partition coefficient, Directive 92/69/EEC, published in OJ No L 383 A, 1992. With respect to the character of the test substance (a mixture of compounds) and to the results of QSAR estimations of Log Pow of main components it was concluded that the partition coefficient of Weikoform could be evaluated only by means of a calculation method. The partition coefficients of all main components of the test substance were calculated. For the confirmation of calculated values of the partition coefficients, an HPLC experiment was performed, the results of which were in accordance with calculation (except for Methenamin, where HPLC method is still inapplicable).
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