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EC number: 205-498-5 | CAS number: 141-75-3
Endpoint summary
Administrative data
Description of key information
Additional information
In aquatic systems, butyryl chloride (CAS 141-75-3) hydrolyses quickly and forms HCl (CAS 7647-01-0) and butyric acid (CAS 107-92-6) (for details see section 5.1.2). Data from HCl have not been taken into consideration as observed effects are caused by a pH-shift in the test medium.
Short-term toxicity to fish
Parent compound butyryl chloride (CAS 141-75-3): BASF, 1998, 10F0451/965162, OECD 203, Danio rerio, analytically verified test concentrations, 96h LC50 = 299 mg/L (not neutralized), 96h LC50 > 464 mg/L (neutralized)
Based on the available data, butyryl chloride is with high probability acutely not harmful to fish.
Hydrolysis product butyric acid (CAS 170-92-6): BASF SE, 2022, QSAR KATE2020, 96h LC50 = 340 mg/L, substance within the applicability domain of the model
Based on the available data, butyric acid is with high probability acutely not harmful to fish.
Isobutyric acid (CAS 79-31-2): BASF SE, 2022, QSAR KATE2020, 96h LC50 = 370 mg/L, substance within the applicability domain of the model
Based on the available data, isobutyric acid is with high probability acutely not harmful to fish.
Short-term toxicity to aquatic invertebrates
Parent compound butyryl chloride (CAS 141-75-3): No data available.
Hydrolysis product butyric acid (CAS 170-92-6): No data available. The risk assessment is therefore based on read-across to the structurally similar substance isobutyric acid (CAS 79-31-2).
Isobutyric acid (CAS 79-31-2):
BASF, 1989, 1/0244/2/89-0244/89, German Industrial Standard DIN 38412,
part 11 (similar to OECD 202), Daphnia magna, analytically
verified test concentrations, 48h EC50 = 51.25 mg/L
Taking into account the results of isobutyric acid the test substance butyryl chloride and its hydrolysis product butyric acid are expected to be acutely harmful to aquatic invertebrates.
Toxicity to aquatic algae
Parent compound butyryl chloride (CAS 141-75-3): No data available.
Hydrolysis product butyric acid (CAS 170-92-6): No data available. The risk assessment is therefore based on read-across to the structurally similar substance isobutyric acid (CAS 79-31-2).
Isobutyric acid (CAS 79-31-2): BASF, 1990, 2/0244/89, German Industrial Standard DIN 38412, part 9 (similar to OECD 201), Desmodesmus subspicatus, 72h ErC10 = 33.7 mg/L, 72h ErC50 = 53.9 mg/L
Taking into account the results of isobutyric acid the test substance butyryl chloride and its hydrolysis product butyric acid are expected to be acutely harmful to aquatic algae.
Toxicity to microorganisms
Parent compound butyryl chloride (CAS 141-75-3): No data available.
Hydrolysis product butyric acid (CAS 107-92-6): Schultz, 2011, method according to Schultz, 1997, Tetrahymena pyriformis, 40h EC50 = 329 mg/L
Isobutyric acid (CAS 79-31-2): BASF, 1989, DIN 38412, part 8, Pseudomonas putida, 17h EC10 = 39 mg/L
Taking into account the results of isobutyric acid as a worst case scenario and based on the available results as well as depending on local conditions and existing concentrations, disturbances in the biodegradation process of activated sludge are possible.
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