Registration Dossier
Registration Dossier
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EC number: 405-820-6 | CAS number: 30025-38-8
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
48hr EC50 >150mg/l, QSAR estimate: 2297mg/l.
Key value for chemical safety assessment
Additional information
In a guideline (OECD 202) and GLP acute toxicity study (48 -hr; static), Daphnia magna were exposed to dipropylene glycol monoethyl ether at concentrations up to 150 mg/L. Based on the findings of this study the 48 -hr EC50 for immobilization of daphnia by DPGEE was extrapolated to be ~180 mg/L (77 - 425 95% CL). This result seems unusually low and is in fact lower than the NOEC from the reproduction (chronic) study; US EPA ECOSAR software (v1.00a) estimates the 48 -hr Daphnid LC50 for dipropylene glycol monoethyl etherto be 2297 mg/L, respectively. This difference should be taken into account in the choice of appropriate starting points and assessment factors for the derivation of the short term PNEC.
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