Registration Dossier
Registration Dossier
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EC number: 245-178-2 | CAS number: 22722-98-1
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2004-2005
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 005
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- GLP compliance:
- yes
- Test type:
- other: Limit Test
- Limit test:
- yes
Test material
- Reference substance name:
- Sodium dihydridobis(2-methoxyethanolato)aluminate(1-)
- EC Number:
- 245-178-2
- EC Name:
- Sodium dihydridobis(2-methoxyethanolato)aluminate(1-)
- Cas Number:
- 22722-98-1
- Molecular formula:
- C6H16AlO4.Na
- IUPAC Name:
- sodium dihydridobis(2-methoxyethanolato)aluminate(1-)
- Details on test material:
- 70% hydride solution in Toluene carrier (as supplied)
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- 4 female animals. Housed Singly, standard conditions.
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Duration of exposure:
- 24 hours
- Doses:
- 400 mg/kg bw
- No. of animals per sex per dose:
- 4 females
- Control animals:
- not required
Results and discussion
Effect levels
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 400 mg/kg bw
- Based on:
- other: Substance in Toluene carrier
- Mortality:
- All animals survived.
- Clinical signs:
- Skin effects only - blanching, discolouration, eschar and/or hyperkeratosis.
- Body weight:
- Unchanged
- Gross pathology:
- Skin effects only - blanching, discolouration, eschar and/or hyperkeratosis.
Applicant's summary and conclusion
- Interpretation of results:
- harmful
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Dermal LD 50 >400mg/kg bw
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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