Registration Dossier
Registration Dossier
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EC number: 204-820-1 | CAS number: 127-06-0
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Test method poorly described. No data on GLP.
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 982
- Report date:
- 1982
Materials and methods
- Principles of method if other than guideline:
- The acute LD50 was determined after ip injection of test compound solutions in distilled water. The 7-day survival was recorded.
No more data on test method was reported. - GLP compliance:
- not specified
Test material
- Reference substance name:
- Acetone oxime
- EC Number:
- 204-820-1
- EC Name:
- Acetone oxime
- Cas Number:
- 127-06-0
- Molecular formula:
- C3H7NO
- IUPAC Name:
- acetone oxime
- Details on test material:
- - Name of test material (as cited in study report): Acetoxime
- It was recrystallized twice from hot methanol (cooled to -20 ºC) to yield white crystals.
- Analysis indicated:
a) calculated: C, 49.3; H, 9.65; and N, 19.2%
b) found: C, 49.1; H, 9.88; and N, 19.3%.
- Solutions in water were stable for 1 day at 22 ºC and for 3 days at 4 ºC, as determined by their UV absorption at 195 nm.
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: From the breeding colony of The Eppley Institute.
- Age at study initiation: From 8 to 10 weeks of age.
- Housing: 4 or 5/cage
- Diet (e.g. ad libitum): Wayne Lab Blox pellets (Allied Mills, Inc., Chicago, III).
- Water (e.g. ad libitum): Tap water.
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- water
- Doses:
- No data
- No. of animals per sex per dose:
- No data
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 7 days
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 840 mg/kg bw
- Based on:
- test mat.
Any other information on results incl. tables
The acute LD50 of Acetoxime was 840 mg/kg bw.
Applicant's summary and conclusion
- Conclusions:
- The acute LD50 of Acetoxime was 840 mg/kg bw.
- Executive summary:
The acute LD50 was determined after ip injection of Acetoxime solutions in distilled water. The 7-day survival was recorded.
The acute LD50 of Acetoxime was 840 mg/kg bw.
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