Registration Dossier
Registration Dossier
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EC number: 204-634-0 | CAS number: 123-54-6
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Additional information:
The skin sensitising properties of 2,4-pentanedione were examined in five guinea pigs and in a human patch test consisting of 12 volunteers. No detailed description of the methods applied was available for both the animal and human patch test study. It was reported that five guinea pigs were treated on the basis of a standardised skin sensitisation test and 1/5 guinea pigs revealed a weak response while the remaining 4/5 animals remained normal. The overall result of the study was evaluated as ambiguous by the study authors (Eastman Kodak, 1979). In the patch test study with human volunteers no information was available concerning gender and health status as well as a possible allergic predisposition of the test persons. Of the 12 persons tested three of them showed no, seven doubtful and two a positive reaction after an exposure period of 24 hours. No skin reactions were evident after 48 and 72 hours, respectively. The results observed in the human patch test were interpreted as an irritating rather than a sensitising effect and it was concluded by the authors that sensitisation might occur more frequently due to prolonged and close skin contact of pads containing the substance (Steny and Schmoll, 1985). However, due to both the poor description of the study and the very weak irritating potential of the compound a verification of the results described is lacking.
An in silico analysis of pentane-2,4 -dione by means of an QSAR analysis (OASIS TIMES) yielded a positive result and predicted a strong skin sensitization potential. Since all domaines (total, structural, mecanistic and parametric) were in domaine (100% correct fragments for structural and mechanistic domaine) it appears justifiable to use this result for a classification decision.
Overall, a sensitising potential of the substance can be assumed on the basis of all data.
Migrated from Short description of key information:
Available data not sufficient for assessment.
Justification for classification or non-classification
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