Registration Dossier
Registration Dossier
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EC number: - | CAS number: -
Short-term toxicity to aquatic invertebrates
Administrative data
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Conducted at GLP-accredited facility to current guidelines
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 017
- Report date:
- 2017
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
Test material
- Test material form:
- liquid
Constituent 1
Sampling and analysis
- Analytical monitoring:
- yes
- Details on sampling:
- Analytical samples taken at 0 hours (initial value) and 24 hours from fresh and 48 hours aged test solutions were analysed from control, solvent control and all test item concentrations.
Test organisms
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- Daphnia magna Straus, Clone V, max. 24 hours old.
Study design
- Test type:
- semi-static
- Water media type:
- freshwater
- Total exposure duration:
- 48 h
Test conditions
- Hardness:
- The total hardness (as CaCO3) of the untreated control was determined to be 13°dH (232 mg/L CaCO3).
- Test temperature:
- The mean temperature of the control, solvent control and all test item concentrations was measured to be 19.9 ± 0.7 °C (Std. Dev.).
- pH:
- The mean pH-value of the untreated control was determined to be 8.01 ± 0.12 (Std. Dev.).
- Dissolved oxygen:
- The mean oxygen concentration was determined to be 8.8 ± 0.1 mg/L (Std. Dev.).
Results and discussion
Effect concentrationsopen allclose all
- Key result
- Duration:
- 24 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 50 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Key result
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 50 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Key result
- Duration:
- 24 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 50 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Key result
- Duration:
- 48 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 50 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- According to the results of the test, the EC50 (48 h) was supposed to be > 50.0 mg/L (nominal) and > 40.5 mg/L (actual). The corresponding NOEC (48 h) was 50.0 mg/L (nominal) and 40.5 mg/L (actual).
- Executive summary:
According to the results of the test, the EC50 (48 h) was supposed to be > 50.0 mg/L (nominal) and > 40.5 mg/L (actual). The corresponding NOEC (48 h) was 50.0 mg/L (nominal) and 40.5 mg/L (actual).
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