4-O-β-D-galactopyranosyl-D-glucitol

Boiling point

Administrative data

Endpoint:

boiling point

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2020

Report date:

2020

Materials and methods

Test guideline

Test guideline 1

Qualifier:

according to guideline

Guideline:

EPA OPPTS 830.7220 (Boiling Point / Boiling Range)

Deviations:

no

Test guideline 2

Qualifier:

according to guideline

Guideline:

OECD Guideline 103 (Boiling Point)

Deviations:

no

Test guideline 3

Qualifier:

according to guideline

Guideline:

EU Method A.2 (Boiling Temperature)

Deviations:

no

GLP compliance:

yes

Type of method:

other: capillary technique

Test material

Test material information

Constituent 1

Reference substance name:

4-O-β-D-galactopyranosyl-D-glucitol

EC Number:

209-566-5

EC Name:

4-O-β-D-galactopyranosyl-D-glucitol

Cas Number:

585-86-4

Molecular formula:

C12H24O11

IUPAC Name:

4-O-beta-D-galactopyranosyl-D-glucitol

Specific details on test material used for the study:

DETAILS OF TEST MATERIAL
- Purity:100%
- Physical Description: White powdery solid
- pH: 5.1
- Stability: Test substance was expected to be stable for the duration of testing.
- Expiration Date: June 29, 2024
- Test substance was stored at room temperature; Testing was carried out on the test substance as received.

Results and discussion

Boiling point

Boiling pt.:

152.1 °C

Decomposition:

yes

Decomp. temp.:

152.1 °C

Remarks on result:

other: decomposition observed as colour change from white to yellow

Any other information on results incl. tables

	Boiling Ranges Observed (⁰C)		Decomposition Observed  (⁰C)
Replicate Number	Final		Individual	Mean± SD
1	151.9		151.9	152.1  ±  0.2
2	152.2		152.2

Applicant's summary and conclusion

Conclusions:

Decomposition was observed, signalled by a colour change from white to yellow; therefore, the test was stopped, and the result reported as the temperature decomposition was observed. The boiling point of the test substance was 152.1°C.

Executive summary:

The boiling point of the test substance was examined in accordance with OECD Guideline 103. The test substance was pressed into a clean capillary tube to form a column of appropriate length (about 3-5 mm). The packed capillary tube was inserted in the apparatus on the side of the heating block and positioned for optimal viewing. The plateau was set at 10°C below the expected boiling point at a ramp rate of 2.0°C per minute and the test was initiated. The temperature (°C) at which the initiation of rapid bubble evolution was observed, was recorded as the boiling point. Heating of the test substance was continued until decomposition of the test substance or a drop in the boiling temperature was observed. This procedure was conducted with water to verify the method and repeated with the test substance to obtain two measurements. Decomposition was observed, signalled by a colour change from white to yellow; therefore, the test was stopped, and the result reported as the temperature decomposition was observed. The boiling point of lactitol was 152.1°C.