Registration Dossier
Registration Dossier
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EC number: 202-928-3 | CAS number: 101-25-7
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- 1967
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
Data source
Reference
- Reference Type:
- publication
- Title:
- Investigation on the nervous effects of N,N-Dinitroso-pentamethylen-tetramine (Mikrofor N) in rats
- Author:
- Desi, I., Bordas, S., Lehotzky, K. and Hajtman, B.
- Year:
- 1 967
- Bibliographic source:
- Med. Lavoro, Vol. 58, n1, 22-31 (1967)
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- 6w oral and i.p. administration including preliminary experiments on acute i.p. toxic effects; acute poisening test (Bordas and Sziza)
- GLP compliance:
- no
- Test type:
- other: not specified
- Limit test:
- no
Test material
- Reference substance name:
- 3,7-dinitroso-1,3,5,7-tetraazabicyclo[3.3.1]nonane
- EC Number:
- 202-928-3
- EC Name:
- 3,7-dinitroso-1,3,5,7-tetraazabicyclo[3.3.1]nonane
- Cas Number:
- 101-25-7
- Molecular formula:
- C5H10N6O2
- IUPAC Name:
- 3,7-dinitroso-1,3,5,7-tetraazabicyclo[3.3.1]nonane
- Test material form:
- solid
- Details on test material:
- - Chemical name: Dinitrosopentamethylenetetramine
- CAS: 101-25-7
- EC: 202-928-3
- MW: 186.17 g/mol
- pale yellow crystalline powder
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- other: oral: unspecified and i.p.
- Vehicle:
- other: aqueous suspension stabilized with acacia gum
- Details on oral exposure:
- no further details
- Doses:
- Acute oral: 940 mg/kg
Acute i.p.: 640, 420, 280, 200 mg/kg
Subacute i.p.: 180, 150, 120, 80 mg/kg/d - No. of animals per sex per dose:
- Acute oral/i.p.: not specified in detail (i.p. 1-6)
Subacute: 6 EEG group, 10 conditioned reflex group - Control animals:
- other: vehicle control group in the subacute experiment
- Details on study design:
- Acute toxicity was tested in preliminary experiments (oral and i.p., not specified in detail).
In the main experiment, the subacute i.p. toxicity regarding nervous effects was tested in rats including an EEG group and a conditioned reflex group. - Statistics:
- Not specified
Results and discussion
Effect levelsopen allclose all
- Key result
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 940 mg/kg bw
- Based on:
- test mat.
- Sex:
- not specified
- Dose descriptor:
- LD50
- Remarks:
- subacute (6 w)
- Effect level:
- 253 mg/kg bw
- Based on:
- test mat.
- Sex:
- not specified
- Dose descriptor:
- LD100
- Remarks:
- subacute (6w)
- Effect level:
- 470 mg/kg bw
- Based on:
- test mat.
- Mortality:
- Not specified in detail
- Clinical signs:
- other: Preliminary test (acute i.p.): spasmodic attacks; acute oral no details Subacute experiment: At beginning free of symptoms then sudden onset of spasms
- Gross pathology:
- No data for acute administration
- Other findings:
- Subacute experiment: Changes in the nervous system at higher doses i.p.
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
- Conclusions:
- The acute oral toxicity was tested in preliminary experiments resulting in a LD50 of 940 mg/kg bw.
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