[No public or meaningful name is available]

Density

Administrative data

Endpoint:

relative density

Type of information:

experimental study

Adequacy of study:

key study

Study period:

09 September 2019

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2019

Report date:

2019

Materials and methods

Test guideline

Test guideline 1

Qualifier:

according to guideline

Guideline:

OECD Guideline 109 (Density of Liquids and Solids)

Version / remarks:

2012

Deviations:

no

Test guideline 2

Qualifier:

according to guideline

Guideline:

EU Method A.3 (Relative Density)

Version / remarks:

Regulation EC No. 440/2008

Deviations:

no

Test guideline 3

Qualifier:

according to guideline

Guideline:

EPA OPPTS 830.7300 (Density / Relative Density / Bulk Density)

Version / remarks:

2002

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Type of method:

other: gas comparison pycnometer

Test material

Test material information

Constituent 1

Reference substance name:

3-(aminocarbonyl)-1-ß-D-ribofuranosyl-pyridinium bromide

Cas Number:

78687-39-5

Molecular formula:

C11H15BrN2O5

IUPAC Name:

3-(aminocarbonyl)-1-ß-D-ribofuranosyl-pyridinium bromide

impurity 1

Reference substance name:

Nicotinamide

EC Number:

202-713-4

EC Name:

Nicotinamide

Cas Number:

98-92-0

Molecular formula:

C6H6N2O

IUPAC Name:

nicotinamide

impurity 2

Reference substance name:

Methanol

EC Number:

200-659-6

EC Name:

Methanol

Cas Number:

67-56-1

Molecular formula:

CH4O

IUPAC Name:

methanol

impurity 3

Reference substance name:

Ethyl acetate

EC Number:

205-500-4

EC Name:

Ethyl acetate

Cas Number:

141-78-6

Molecular formula:

C4H8O2

IUPAC Name:

ethyl acetate

impurity 4

Reference substance name:

Water

EC Number:

231-791-2

EC Name:

Water

Cas Number:

7732-18-5

Molecular formula:

H2O

IUPAC Name:

Oxidane

impurity 5

Reference substance name:

inorganic salts by sulphated ash

IUPAC Name:

inorganic salts by sulphated ash

impurity 6

Reference substance name:

Bromic acid

EC Number:

232-158-3

EC Name:

Bromic acid

Cas Number:

7789-31-3

Molecular formula:

BrHO3

IUPAC Name:

bromic acid

impurity 7

Reference substance name:

Unknown impurities.

Molecular formula:

Not available as unknown impurities.

IUPAC Name:

Unknown impurities.

Test material form:

solid

Details on test material:

Batch / Lot No. 1000146/01

Specific details on test material used for the study:

Batch No.: 1000146/01
Storage Conditions: Freezer (approx. -15 °C)

Results and discussion

Density

Density 1

Key result

Type:

relative density

Density:

1.661 other: relative density is dimensionless

Temp.:

20 °C

Remarks on result:

other: The relative density is calculated by dividing the density of the test item by the density of water at 4 °C.

Density 2

Type:

density

Density:

1.661 g/cm³

Temp.:

20 °C

Remarks on result:

other: the density of the test item is given as the mean value of two measurements.

Any other information on results incl. tables

The individual density measurements were 1.66100 g/cm3 (test 1) and 1.66152 g/cm3 (test 2).

Applicant's summary and conclusion

Conclusions:

According to OECD Test Guidelines 109 (2012) and EC No. 440/2008 Part A. Method A.3., and OCSPP Test Guideline 830.7300 (2002), the relative density of the test item Nicotinamide-beta-D-riboside bromide (CAS no. 78687-39-5) at 20 °C ± 0.01 °C (compared to water at 4 °C) was determined to be 1.661.

Executive summary:

According to OECD Test Guidelines 109 (2012), Regulation EC No. 440/2008 Method A.3. and EPA OCSPP Test Guideline 830.7300 (2002), the relative density D₄²⁰ of the test item Nicotinamide-beta-D-riboside bromide (CAS no.78687-39-5) at 20 °C ± 0.01 °C (compared to water at 4 °C) is D₄²⁰=1.661.