Registration Dossier
Registration Dossier
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EC number: 202-439-5 | CAS number: 95-65-8
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- Evaluation of feasibility of mutagenic testing of shale oil products and effluents
- Author:
- Epler JL, Rao TK, Guerin MR
- Year:
- 1 979
- Bibliographic source:
- Environmental Health Perspectives 30: 179-184
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- - Principle of test:
bacterial reverse mutation assay with S. typhimurium TA98 and TA100
- Short description of test conditions: with and without metabolisation, revertants counted after 2-day incubation - GLP compliance:
- no
- Type of assay:
- bacterial reverse mutation assay
Test material
- Reference substance name:
- 3,4-xylenol
- EC Number:
- 202-439-5
- EC Name:
- 3,4-xylenol
- Cas Number:
- 95-65-8
- Molecular formula:
- C8H10O
- IUPAC Name:
- 3,4-dimethylphenol
Constituent 1
Method
Species / strainopen allclose all
- Species / strain / cell type:
- S. typhimurium TA 98
- Species / strain / cell type:
- S. typhimurium TA 100
- Metabolic activation:
- with and without
Controls
- Positive controls:
- yes
Results and discussion
Test resultsopen allclose all
- Species / strain:
- S. typhimurium TA 98
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- not specified
- Species / strain:
- S. typhimurium TA 100
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- not specified
Applicant's summary and conclusion
- Conclusions:
- 3,4-xylenol tested negative in a bacterial reverse mutation assay with S. typhimurium TA98 and TA100.
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