Registration Dossier
Registration Dossier
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EC number: 239-570-2 | CAS number: 15529-67-6
Biodegradation in water: screening tests
Administrative data
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 28 days
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Justification for type of information:
- Published research covering the biodegradability of alkyl lactates and lactic acid.
The research concludes that the rate of biodegradation is closely corrolated to partition coeficient with higher water solublity leading to more rapid biodegradation.
Considered reliable research covering any type of lactate.
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 998
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 301 D (Ready Biodegradability: Closed Bottle Test)
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 301 F (Ready Biodegradability: Manometric Respirometry Test)
- Principles of method if other than guideline:
- Different methods were used, but those relating to oxygen consumption were reported (Closed Bottle and Manometric methds)
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Lactic acid
- EC Number:
- 200-018-0
- EC Name:
- Lactic acid
- Cas Number:
- 50-21-5
- Molecular formula:
- C3H6O3
- IUPAC Name:
- 2-Hydroxypropanoic acid
Constituent 1
Study design
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge, domestic, non-adapted
- Details on inoculum:
- Inoculum was prepared from activated sludge originating from domestic sewage.
- Duration of test (contact time):
- 28 d
Initial test substance concentration
- Initial conc.:
- ca. 3 mg/L
- Based on:
- ThOD
Parameter followed for biodegradation estimation
- Parameter followed for biodegradation estimation:
- O2 consumption
Results and discussion
% Degradationopen allclose all
- Parameter:
- % degradation (DOC removal)
- Value:
- ca. 50
- Sampling time:
- 5 d
- Parameter:
- % degradation (DOC removal)
- Value:
- ca. 67
- Sampling time:
- 28 d
- Details on results:
- Only 2 time points reported.
All water soluble lactates resulted in rapid biodegradation, mostly exceeding 60% after 28 days
Applicant's summary and conclusion
- Validity criteria fulfilled:
- not specified
- Remarks:
- Details of controls were not included
- Interpretation of results:
- readily biodegradable, but failing 10-day window
- Conclusions:
- Lactic acid and lactate salts are major metabolites found in living cells. Lactates are readily consumed in foods (milk).
Rapid biodegradation was expected.
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