Registration Dossier
Registration Dossier
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EC number: 219-919-5 | CAS number: 2571-88-2
Endpoint summary
Administrative data
Description of key information
- The LD50 female rat is 1 706 mg/kgbw
- The LD50 male rat is 7 489 mg/kgbw
As indicated in the read-across justification, data from Amine oxide can be used for read-across to N,N-Dimethyl-1-octadecanamine-N-oxide (CAS 2571-88-2 / EINECS 219-919-5) acute oral toxicity.
Concerning the read-across approach, the data on the other C18 Amine Oxide (Dihydroxyethyl oleamine oxide - CAS 93962-62-0) was used to determine the LD50 of N,N-Dimethyl-1-octadecanamine-N-oxide :
And N,N-Dimethyl-1-octadecanamine-N-oxide is considered as Oral Acute Tox, H302 based on the effect on the female rat.
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- read-across based on grouping of substances (category approach)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- REPORTING FORMAT FOR THE ANALOGUE APPROACH
See 2018_Read-across-Justification_V1 in attached justification - Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.1 (Acute Toxicity (Oral))
- Key result
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- ca. 1 706 mg/kg bw
- Based on:
- other: Based on Amine Oxides
- Interpretation of results:
- Category 4 based on GHS criteria
- Conclusions:
- As indicated in the read-across justification, data from Amine oxide can be used for read-across to N,N-Dimethyl-1-octadecanamine-N-oxide (CAS 2571-88-2 / EINECS 219-919-5) acute oral toxicity.
Concerning the read-across approach, the data on the other C18 Amine Oxide (Dihydroxyethyl oleamine oxide - CAS 93962-62-0) was used to determine the LD50 of N,N-Dimethyl-1-octadecanamine-N-oxide :
- The LD50 female rat is 1 706 mg/kgbw
- The LD50 male rat is 7 489 mg/kgbw - Executive summary:
As indicated in the read-across justification, data from Amine oxide can be used for read-across to N,N-Dimethyl-1-octadecanamine-N-oxide (CAS 2571-88-2 / EINECS 219-919-5) acute oral toxicity.
Concerning the read-across approach, the data on the other C18 Amine Oxide (Dihydroxyethyl oleamine oxide - CAS 93962-62-0) was used to determine the LD50 of N,N-Dimethyl-1-octadecanamine-N-oxide :
- The LD50 female rat is 1 706 mg/kgbw
- The LD50 male rat is 7 489 mg/kgbw
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 1 706 mg/kg bw
Additional information
Justification for classification or non-classification
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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