Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
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EC number: - | CAS number: -
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- June 2005
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- Final Report on the Safety Assessment of Oleic Acid, Lauric Acid, Palmitic Acid, Myristic Acid, and Stearic Acid
- Author:
- Unknown
- Year:
- 2 005
- Bibliographic source:
- Journal of the American College of Toxicology
Materials and methods
Test guideline
- Guideline:
- other: information not available
- GLP compliance:
- not specified
- Remarks:
- information not available
Test material
- Reference substance name:
- Myristic acid
- EC Number:
- 208-875-2
- EC Name:
- Myristic acid
- Cas Number:
- 544-63-8
- Molecular formula:
- C14H28O2
- IUPAC Name:
- Tetradecanoic acid
- Test material form:
- solid
Constituent 1
- Specific details on test material used for the study:
- Commercial grade myristic acid and 50% myristic acid in petrolatum.
Test animals / tissue source
- Species:
- rabbit
- Strain:
- not specified
- Details on test animals or tissues and environmental conditions:
- Albino rabbits
Test system
- Vehicle:
- not specified
- Amount / concentration applied:
- commercial grade myristic acid and 50% myristic acid in petrolatum
- Duration of treatment / exposure:
- 1 day
- Observation period (in vivo):
- 1 day
- Details on study design:
- Lotion formulations containing 1.5% myristic acid were applied to rinsed (20 mL ionized water at room temperature, 30 seconds after instillation) and unrinsed treated eyes of rabbits.
Results and discussion
In vivo
Results
- Irritation parameter:
- other: not specified
- Basis:
- other: not specified
- Time point:
- 24 h
- Remarks on result:
- probability of mild irritation
- Remarks:
- Formulations were minimally irritating to rinsed and unrinsed treated eyes of rabbits
Applicant's summary and conclusion
- Interpretation of results:
- Category 2 (irritating to eyes) based on GHS criteria
- Conclusions:
- Lotion formulations containing 1.5% myristic acid were minimally irritating to rinsed (20 mL ionized water at room temperature, 30 seconds after instillation) and unrinsed treated eyes of rabbits.
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