Registration Dossier
Registration Dossier
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EC number: 608-148-3 | CAS number: 279246-65-0
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 20.-28.06.2007
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 123 (Partition Coefficient (1-Octanol / Water), Slow-Stirring Method)
- GLP compliance:
- yes
- Type of method:
- slow-stirring method
- Partition coefficient type:
- octanol-water
- Analytical method:
- gas chromatography
- Key result
- Type:
- log Pow
- Partition coefficient:
- 6.4
- Temp.:
- 25 °C
- Remarks on result:
- other: pH not relevant
- Conclusions:
- The partition coefficient n-octanol/water of the test item was determined according to the slow stirring method. It was found to be 6.4.
- Executive summary:
A study was conducted in accordance with OECD Guideline for Testing of Chemicals, Guideline No. 123: "Partition coefficient(1 -octanol/water): Slow Stirring Method, adopted March 23, 2006 to determine the partition coefficient of the test substance. The partition coefficient n-octanol/water of the test item was determined according to the slow stirring method. It was found to be 6.4 using the slow-stirring method at 25 °C +/- 1 °C.
Reference
Calculated particion coefficient of the test item:
The partition coefficient was calculated based on the results of the analytical determination. The log Pow was calculated for each replicate. From the results of a non-GLP pre-experiment it was assumed that equilibrium was reached as the 1 -octanol/water concentration ratio did not change significantly in samples taken over a time period of 120 h. The test item was determined to almost 100 % in the octanol phase. The concentration in the aqueous phase was below the quantification limit. For calculation purpose the LOQ was used. The difference between the three replicates was less than +/- 0.1 log units.
According to the results of this study the logarithmic partition coefficient (n-octanol / water) of the test item was calculated to be 6.4 using the slow-stirring method at 25 °C +/- 1 °C.
Description of key information
The partition coefficient n-octanol/water of the test item was determined according to the slow stirring method. It was found to be 6.4.
Key value for chemical safety assessment
- Log Kow (Log Pow):
- 6.4
- at the temperature of:
- 25 °C
Additional information
A study was conducted in accordance with OECD Guideline for Testing of Chemicals, Guideline No. 123: "Partition coefficient(1 -octanol/water): Slow Stirring Method, adopted March 23, 2006 to determine the partition coefficient of the test substance. The partition coefficient n-octanol/water of the test item was determined according to the slow stirring method. It was found to be 6.4 using the slow-stirring method at 25 °C +/- 1 °C.
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