Propane-1,3-diyl bis(4-aminobenzoate)

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Study period:

1974

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

study well documented, meets generally accepted scientific principles, acceptable for assessment

Remarks:

Study period preceeds GLP

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1974

Report date:

1974

Materials and methods

Test guideline

Qualifier:

no guideline followed

Version / remarks:

Test date preceeds guidlines

Principles of method if other than guideline:

ndividual groups of five young Swiss albino mice weighing approximately 23 grams were administered intragastrically doses of 4,000 and 5,000 rng per kilogram using a 1.0 tuberculin syringe with an 18-gauge stomach tube attachment. Animals were denied food for 24 hours prior to intubation.

GLP compliance:

no

Remarks:

Test date preceeds GLP

Test type:

standard acute method

Limit test:

yes

Test material

Test material information

Constituent 1

Reference substance name:

Propane-1,3-diyl bis(4-aminobenzoate)

EC Number:

260-847-9

EC Name:

Propane-1,3-diyl bis(4-aminobenzoate)

Cas Number:

57609-64-0

Molecular formula:

C17H18N2O4

IUPAC Name:

3-(4-aminobenzoyloxy)propyl 4-aminobenzoate

Test animals

Species:

mouse

Strain:

Swiss

Sex:

not specified

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

unchanged (no vehicle)

Details on oral exposure:

Individual groups of five young Swiss albino mice weighing approximately 23 grams were administered intragastrically doses of 4,000 and 5,000 rng per kilogram using a 1.0 tuberculin syringe with an 18-gauge stomach tube attachment. Animals were denied food for 24 hours prior to intubation.

Doses:

4 and 5 g per kg bw

No. of animals per sex per dose:

5 animals per dose

Control animals:

no

Details on study design:

Individual groups of five young Swiss albino mice weighing approximately 23 grams were administered intragastrically doses of 4,000 and 5,000 rng per kilogram using a 1.0 tuberculin syringe with an 18-gauge stomach tube attachment. Animals were denied food for 24 hours prior to intubation.

Surviving animals were observed daily for 7 days to determine if and when mortality occurred. Upon termination of one observation peri'od< surviving animals would be necropsied and examined for gross evidence of pathology.

Results and discussion

Effect levels

Key result

Sex:

not specified

Dose descriptor:

LD50

Effect level:

> 5 000 mg/kg bw

Based on:

test mat.

Mortality:

none

Gross pathology:

At necropsy no gross variable was noted involving organs or tissues.

Applicant's summary and conclusion

Interpretation of results:

GHS criteria not met

Conclusions:

Substance is non-toxic.

Executive summary:

LD50 > 5000 mg/kg bw