Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 908-081-2 | CAS number: -
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 23 March 2018 to 19 April 2018
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Deviations:
- not specified
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- column elution method
- Specific details on test material used for the study:
- Batch/Lot Number: 150205
Appearance: Blue powder
Purity: As a UVCB purity is considered as 100% - Key result
- Water solubility:
- < 0.17 mg/L
- Conc. based on:
- test mat.
- Temp.:
- 20 °C
- pH:
- >= 5.9 - <= 6.5
- Details on results:
- Preliminary test: The investigation was performed at 20 °C to get a rough information of the water solubility. Portions of the test item were added to distilled water and were stirred for at least 48 hours in a water bath at 20°C. Measuring the content of copper in the filtered solutions outside GLP showed a water solubility far below 10 mg /L. Therefore the column elution method at one temperature (20 °C) was carried out according to the guidelines.
Main test: The results of the solubility of "B440" in water at 20 °C are listed in Table 1 to Table 2. The temperature of the water bath was 20 °C at run A and B. The pH of the solutions was 5.9 to 6.5 for run A and B. The mean water solubility of "B440" in water at 20 °C was < 0.17 mg / L, 5 replicates, at a flow of 25.0 ml / h and < 0.17 mg / L, 5 replicates, at a flow of 12.5 ml / h. The mean water solubility of "B440" in water at 20 °C was < 0.17 mg/L, 2 replicates. In each replicate run the water solubility of the test substance was less than the limit of quantification (0.17 mg / L) of the analytical method. - Conclusions:
- The mean water solubility of "B440" in water at 20 °C was < 0.17 mg/L, 2 replicates. In each replicate run the water solubility of the test substance was less than the limit of quantification (0.17 mg / L) of the analytical method.
Due to the low water solubility the temperature coefficient of the solubility of the test substance cannot be determined, therefore no further tests at other temperatures were performed, in agreement with the guideline.
Reference
Table 1
description |
date / time |
flow |
total bed volume |
pH |
copper content in water |
test item concentration in water |
deviation from the mean concentration |
Start |
2018-04-18 09:55 |
25 |
0 |
-- |
-- |
-- |
-- |
1 |
2018-04-18 10:55 |
25 |
10 |
6.4 |
< 0.017 |
< 0.17 |
-- |
2 |
2018-04-18 12:10 |
25 |
22 |
6.0 |
< 0.017 |
< 0.17 |
-- |
3 |
2018-04-18 13:20 |
25 |
34 |
5.9 |
< 0.017 |
< 0.17 |
-- |
4 |
2018-04-18 14:35 |
25 |
46 |
5.9 |
< 0.017 |
< 0.17 |
-- |
5 |
2018-04-18 15:50 |
25 |
59 |
5.9 |
< 0.017 |
< 0.17 |
-- |
|
|
|
Mean |
6.0 |
< 0.017 |
< 0.17 |
|
Table 2
description |
date / time |
flow |
total bed volume |
pH |
copper content in water |
test item concentration in water |
deviation from the mean concentration |
Start |
2018-04-18 09:55 |
12.5 |
0 |
-- |
-- |
-- |
-- |
1 |
2018-04-18 12:00 |
12.5 |
10 |
6.5 |
< 0.017 |
< 0.17 |
-- |
2 |
2018-04-18 14:30 |
12.5 |
22 |
6.1 |
< 0.017 |
< 0.17 |
-- |
3 |
2018-04-19 08:00 |
12.5 |
110 |
5.9 |
< 0.017 |
< 0.17 |
-- |
4 |
2018-04-19 10:25 |
12.5 |
122 |
5.9 |
< 0.017 |
< 0.17 |
-- |
5 |
2018-04-19 12:50 |
12.5 |
134 |
5.9 |
< 0.017 |
< 0.17 |
-- |
|
|
|
Mean |
6.1 |
< 0.017 |
< 0.17 |
|
Description of key information
Mean water solubility was found to be less than 0.17 mg/L at 20°C.
Key value for chemical safety assessment
- Water solubility:
- 0.17 mg/L
- at the temperature of:
- 20 °C
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
