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EC number: 204-110-1 | CAS number: 115-83-3
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Remarks:
- Summary of available data used for the endpoint assessment of the target substance.
- Adequacy of study:
- key study
- Justification for type of information:
- Please refer to the Analogue Justification provided in IUCLID section 13.
- Reason / purpose for cross-reference:
- other:
- Reason / purpose for cross-reference:
- other:
- Duration:
- 48 h
- Dose descriptor:
- EL50
- Effect conc.:
- > 1 072 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Remarks:
- (WAF)
- Basis for effect:
- mobility
- Remarks on result:
- other: source, RA-A, CAS 71010-76-9, Exxon, 2006, D. magna 48 h, RL1
- Duration:
- 48 h
- Dose descriptor:
- EL0
- Effect conc.:
- >= 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Remarks:
- (WAF)
- Basis for effect:
- mobility
- Remarks on result:
- other: source, RA-A, CAS 68604-44-4, BASF, 1998, D. magna 48 h, RL2
- Duration:
- 48 h
- Dose descriptor:
- EL50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Remarks:
- (WAF)
- Basis for effect:
- mobility
- Remarks on result:
- other: source, RA-A, CAS 68604-44-4, BASF, 1998, D. magna 48 h, RL2
- Duration:
- 48 h
- Dose descriptor:
- EL100
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Remarks:
- (WAF)
- Basis for effect:
- mobility
- Remarks on result:
- other: source, RA-A, CAS 68604-44-4, BASF, 1998, D. magna 48 h, RL2
Reference
Description of key information
No effects up to the limit of water solubility; read-across.
Key value for chemical safety assessment
Additional information
No study investigating the short-term toxicity of pentaerythritol tetrastearate (CAS 115-83-3) to aquatic invertebrates is available. Therefore, in accordance to Regulation (EC) No. 1907/2006 Annex XI, 1.5 a read-across to the structurally related source substances decanoic acid, mixed esters with heptanoic acid, octanoic acid, pentaerythritol and valeric acid (CAS 71010-76-9) and fatty acids, C16-18 and C18-unsatd., tetraesters with pentaerythritol (CAS 68604-44-4) is applied.
Based on the high degree of similarity between the structural and physico-chemical properties of the target and source substances, the source substances are considered as suitable representative for the evaluation of the short-term toxicity of the target substance to aquatic invertebrates. The read-across approach is justified in detail within the analogue justification in IUCLID section 13.
The short-term toxicity of decanoic acid, mixed esters with heptanoic acid, octanoic acid, pentaerythritol and valeric acid (CAS 71010-76-9) to aquatic invertebrates was investigated according to OECD 202 using Daphnia magna as test organism under static conditions. Testing was done with the water-accommodated fraction (WAF). The WAFs were prepared by adding the appropriate amount of test substance with subsequent stirring and sampling of the aqueous portions through the outlet at the bottom of the vessels. Loading rate WAFs of 62, 132, 251, 503 and 1072 mg/L were tested. No immobilisation was observed in any treatment and the control throughout the test period of 48 h. Hence, the 48 h EL50 is determined to be > 1072 mg/L based on the nominal test concentration. The second study investigated the short-term toxicity to aquatic invertebrates of fatty acids, C16-18 and C18-unsatd., tetraesters with pentaerythritol (CAS 68604-44-4). The study was performed under static conditions according to EU Method C.2 using Daphnia magna as test organism. As for the previous study, testing was done with the water-accommodated fraction (WAF).The WAF was prepared by adding the appropriate amount of test substance with subsequent stirring and filtering. A nominal test concentration of 100 mg/L was tested, corresponding to < 10 mg/L (detection limit). No immobilization was observed in the treatment and the control throughout the test period of 48 h. Hence, the 48 h-EL50 is determined to be > 100 mg/L based on the nominal test concentration.
Based on the available results from structurally related source substances (in accordance to Regulation (EC) No 1907/2006 Annex XI, 1.5) which are characterized by a similar ecotoxicological profile and comparable structure, it can be concluded that pentaerythritol tetrastearate (CAS 115-83-3) will not exhibit short-term effects to aquatic invertebrates up to the limit of water solubility.
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