Disodium naphthalene-1,5-disulphonate

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Study period:

15 - 29 Mar 1989

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: GLP compliant study conducted similar to OECD guideline 401 with only minor limitations

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1989

Report date:

1989

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 401 (Acute Oral Toxicity)

Deviations:

not applicable

GLP compliance:

yes

Test type:

standard acute method

Limit test:

yes

Test material

Test material information

Constituent 1

Reference substance name:

1,5-naphthylenediamine

EC Number:

218-817-8

EC Name:

1,5-naphthylenediamine

Cas Number:

2243-62-1

Molecular formula:

C10H10N2

IUPAC Name:

naphthalene-1,5-diamine

Constituent 2

Reference substance name:

1,5-naphtylenediamine

IUPAC Name:

1,5-naphtylenediamine

Details on test material:

IUCLID4 Test substance: other TS: purity 89-90 % (chromatography indicated an impurity)

Test animals

Species:

rat

Strain:

Wistar

Sex:

male/female

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

other: demineralised water

Doses:

2000 mg/kg bw (nominal)

No. of animals per sex per dose:

5

Control animals:

no

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

LD0

Effect level:

2 000 mg/kg bw

Based on:

test mat.

Remarks on result:

other: No mortality and no signs of systemic toxicity were observed