Dodecyl laurate

Short-term toxicity to fish

Link to relevant study record(s)

Reference

Endpoint:

short-term toxicity to fish

Type of information:

read-across from supporting substance (structural analogue or surrogate)

Remarks:

Summary of available data used for the endpoint assessment of the target substance.

Adequacy of study:

key study

Justification for type of information:

Refer to the analogue approach justification provided in IUCLID section 13.

Reason / purpose for cross-reference:

read-across source

Reason / purpose for cross-reference:

read-across source

Duration:

96 h

Dose descriptor:

LC50

Effect conc.:

> 100 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

mortality (fish)

Remarks on result:

other:

Remarks:

Source: RA-A, CAS 3234-85-3, Evonik, 2012, D. rerio, 96 h

Duration:

96 h

Dose descriptor:

LC50

Effect conc.:

> 0.189 µg/L

Nominal / measured:

meas. (initial)

Conc. based on:

test mat.

Basis for effect:

mortality (fish)

Remarks on result:

other:

Remarks:

Source: RA-A, CAS 3234-85-3, Evonik, 2012, D. rerio, 96 h

Duration:

96 h

Dose descriptor:

LL50

Effect conc.:

> 100 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

mortality (fish)

Remarks on result:

other:

Remarks:

Source: RA-A, CAS 95912-86-0, BASF, 2013, D. rerio, 96 h, RL1

Conclusions:

The key values retained for the short-term toxicity of the target substance to fish are an LC50 (96 h)/LL50 (96 h) of > 100 mg/L (nominal) and of > 0.189 µg/L (meas. initial), respectively, based on experimental results with two structurally and chemically similar source substances (OECD 203, D.rerio); read-across

Description of key information

No toxic effects up to the limit of water solubility (OECD 203, D. rerio); read-across

Additional information

There is no study available, in which the short-term toxicity of lauryl laurate (CAS 13945-76-1) to fish was investigated. Therefore, read-across to the structurally related source substances tetradecyl myristate (CAS 3234-85-3) and fatty acids, C8-10, C12-18-alkyl esters (CAS 95912-86-0) was performed in accordance with Regulation (EC) No 1907/2006 Annex XI, 1.5. The source substances are characterized by similar fatty acid chain lengths as well as alcohol components and are therefore considered suitable representatives for the assessment of the short-term toxicity of the target substance to fish. A detailed read-across justification is provided in the analogue justification in IUCLID section 13.

Both the available studies were conducted according to OECD guideline 203 and GLP.

In the available study with the source substance fatty acids, C8-10, C12-18-alkyl esters (CAS 95912-86-0) a semi-static limit test was performed, in which D. rerio was exposed to a water accommodated fraction with a nominal loading rate of 100 mg/L for 96 h.

After 96 h, no mortality was observed, resulting in an LL50 (96 h) > 100 mg/L (nominal) and a NOELR (96 h) ≥ 100 mg/L (nominal). Thus, it can be concluded that fatty acids, C8-10, C12-18-alkyl esters will not cause short-term toxicological effects on fish up to the limit of water solubility.

In the available study with the source substance tetradecyl myristate (CAS 3234-85-3) a static limit test was conducted, in which D. rerio was exposed to a Water Accommodated Fraction with a nominal loading rate of 100 mg/L for 96 h. GC/EI-MS analysis resulted in a measured initial concentration of 0.189 µg/L, which dropped below the detection limit (0.1 µg/L) by the end of exposure. After 96 h, no mortality was observed, resulting in an LL50 of > 0.189 µg/L (measured initial concentration) and > 100 mg/L (nominal), respectively. Hence, it can be concluded that tetradecyl myristate does not cause any short-term toxicological effects on fish up to the limit of water solubility.

Based on the structural and chemical similarity of the target and source substances, the target substance is expected to exhibit a similar ecotoxicological profile as the selected source substances. Therefore, it can be concluded that the target substance lauryl laurate (CAS 13945-76-1) does not cause short-term toxicological effects on fish up to the limit of water solubility.