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EC number: 280-479-2 | CAS number: 83547-95-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- 1981
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 203 (Fish, Acute Toxicity Test)
- Version / remarks:
- 1981
- Deviations:
- yes
- Remarks:
- Acclimation of fish was 10 days
- GLP compliance:
- not specified
- Specific details on test material used for the study:
- TEST MATERIAL (as stated in study report): TK 12 184; trade name D 16-51
SOURCE OF TEST MATERIAL
- Source and lot/batch No.of test material: Sponsor / Batch No. Mixt. 4/5/6
STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: room-temperature (20 - 24 deg C)
- Stability under test conditions:
- Solubility and stability of the test substance in the solvent/vehicle:
- Reactivity of the test substance with the solvent/vehicle of the cell culture medium:
TREATMENT OF TEST MATERIAL PRIOR TO TESTING
- Treatment of test material prior to testing:
- Preliminary purification step (if any):
- Final dilution of a dissolved solid, stock liquid or gel:
- Final preparation of a solid:
FORM AS APPLIED IN THE TEST (if different from that of starting material)
TYPE OF BIOCIDE/PESTICIDE FORMULATION (if applicable)
OTHER SPECIFICS: - Analytical monitoring:
- no
- Vehicle:
- yes
- Remarks:
- acetic acid ethyl ester
- Details on test solutions:
- 10 g TK 12 184 were dissolved in 50 ml Acetic acid-ethylester and completed with water to 1000 ml; this emulsion was treated during 30 seconds with ultrasound. Calculated amounts of stock solution to produce the desired test concentrations were given into the water of the aquaria and homogenously distributed with a high speed mixer. A stable emulsion of the test substance was obtained.
Controls: water control, and vehicle control (0.29 mL/L acetic acid ethyl ester, concentration used for the highest test concentration) - Test organisms (species):
- other: Salmo gairdneri
- Details on test organisms:
- TEST ORGANISM
- Source: H. Mändli, Orishof, CH-4410 Liestal
- Length at study initiation: 60.6 mm (52 - 65 mm)
- Weight at study initiation: 1.79 g (1.26 - 2.4 g)
ACCLIMATION
- Acclimation period: 10 days
FEEDING DURING TEST : none - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 96 h
- Hardness:
- 176.56 mg/L CaCO3
- Test temperature:
- 15 +/- 2 deg C
- pH:
- 7.8 - 8.3
- Dissolved oxygen:
- 4.9 - 9.8 mg/L
- Nominal and measured concentrations:
- 5.8, 10, 18, 32, 58 mg/L
- Details on test conditions:
- TEST SYSTEM
- Test vessel: Glass aquaria, 15 1 water
- Aeration: none
- No. of organisms per vessel: 10
- No. of vessels per concentration (replicates): 1
- No. of vessels per control (replicates): 1
- No. of vessels per vehicle control (replicates): 1
- Biomass loading rate: 0.6 g/L
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: Dechlorinated tap water
OTHER TEST CONDITIONS
- Lighting: indirect daylight , 12 hours photoperiod daily
EFFECT PARAMETERS MEASURED (with observation intervals if applicable): mortality, observations and symptoms were recorded daily - Reference substance (positive control):
- no
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- 8.25 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Remarks on result:
- other: 95% confidence limits
- Remarks:
- 6.91 - 9.86 mg/L
- Duration:
- 96 h
- Dose descriptor:
- LC0
- Effect conc.:
- <= 5.8 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Remarks on result:
- other: 1 of 10 organisms dead at 96 h
- Duration:
- 96 h
- Dose descriptor:
- LC100
- Effect conc.:
- 18 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Details on results:
- No mortality occurred in the water control, or in the vehicle control groups.
- Validity criteria fulfilled:
- not specified
- Conclusions:
- Under these guideline test conditions, the LC50 of TK 12 184 in rainbow trout was calculated to be 8.25 mg/L (95% confidence limits: 6.91 - 9.86 mg/11 mg/L)
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- 1982
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 203 (Fish, Acute Toxicity Test)
- Version / remarks:
- 1981
- Deviations:
- no
- GLP compliance:
- not specified
- Specific details on test material used for the study:
- TEST MATERIAL (as stated in study report): TK 12 184; trade name D 16-51
SOURCE OF TEST MATERIAL
- Source and lot/batch No.of test material: Sponsor / Batch No. Mixt. 4/5/6
STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: room temperature (20 - 24 deg C) - Analytical monitoring:
- no
- Vehicle:
- yes
- Remarks:
- acetic acid ethyl ester
- Details on test solutions:
- Stock solution: 1 g TK 12 184 were dissolved in 5 ml aceticacid-ethylester, emulsified with 30 ml water, treated during 30 seconds with ultrasound and completed with water to 100 ml. Calculated amounts of stock solution to produce the desired test concentrations were given into the water of the aquaria and homogenously
distributed with a high speed mixer. A stable emulsion was obtained.
Controls: water control, and vehicle control (0.09 mL/L acetic acid ethyl ester, concentration used for the highest test concentration) - Test organisms (species):
- other: Brachydanio rerio
- Details on test organisms:
- TEST ORGANISM
- Source: West-Aquarium D-3422 Bad Lauterberg
- Length at study initiation: 27 mm (20 - 32 mm)
- Weight at study initiation (mean and range, SD): 0.16 g (0.1 - 0.2 g)
- Loading: 0.1 g/L
ACCLIMATION
- Acclimation period: 12 days
- Type and amount of food during acclimation:
FEEDING DURING TEST : none - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 96 h
- Hardness:
- 195.6 mg/L CaCO3
- Test temperature:
- 23 +/- 2 deg C
- pH:
- 7.8 - 8.5
- Dissolved oxygen:
- 6.9 - 8.3 mg/L
- Nominal and measured concentrations:
- Nominal: 1.8, 3.2, 5.8, 10.0, 18.0 mg/L
- Details on test conditions:
- Water: Dechlorinated tap water
TEST SYSTEM
- Test vessel: Glass aquaria, 15 L water
- Aeration: none
- No. of organisms per vessel: 10
- No. of vessels per concentration (replicates): 1
- No. of vessels per control (replicates): 1
- No. of vessels per vehicle control (replicates): 1
- Biomass loading rate: 0.1 g/L
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: dechlorinated tap water
OTHER TEST CONDITIONS
- Lighting: 16 hours fluorescent light per day
EFFECT PARAMETERS MEASURED (with observation intervals if applicable) : Mortality, observations and symptoms recorded daily - Reference substance (positive control):
- no
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- 4.05 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Remarks on result:
- other: 95 % confidence limits
- Remarks:
- 3.21 - 5.11 mg/L
- Duration:
- 96 h
- Dose descriptor:
- LC0
- Effect conc.:
- 1.8 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Duration:
- 96 h
- Dose descriptor:
- LC100
- Effect conc.:
- 10 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Details on results:
- No mortality occurred in the water control or vehicle control groups.
- Validity criteria fulfilled:
- not specified
- Conclusions:
- Under these guideline test conditions, the LC50 of TK 12 184 in Zebrafish was calculated to be 4.05 mg/L (95% confidence limits: 3.21 - 5.11 mg/L)
- Endpoint:
- short-term toxicity to fish
- Type of information:
- (Q)SAR
- Adequacy of study:
- supporting study
- Study period:
- 2018
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
- Principles of method if other than guideline:
- Results predicted by US EPA ECOSAR v1.11 model.
- GLP compliance:
- no
- Details on results:
- No effects are expected at saturated concentrations in water. The estimated logKow for this substance is greater than the class specific cut-offs for acute fish toxicity, and the predicted effect level exceeds the water solubility of this substance by more than 10x.
- Validity criteria fulfilled:
- not applicable
- Conclusions:
- The US EPA ECOSAR v1.11 model predicts no effects at saturated concentrations in water for TGEPO (CAS No. 83547-95-9). The estimated logKow for this substance is greater than the class specific cut-offs for acute fish toxicity, and the predicted effect level exceeds the estimated water solubility of this substance by more than 10x.
Referenceopen allclose all
Description of key information
The LC50 of water emulsions of TK 12 184 was calculated to be 8.25 mg/L (95% confidence limits: 6.91 - 9.86 mg/11 mg/L) in rainbow trout, and 4.05 mg/L (95% confidence limits: 3.21 - 5.11 mg/L) in Zebrafish. Water emulsions in carrier solvents were prepared due to the low water solubility of the test substance.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 4.05 mg/L
Additional information
The US EPA ECOSAR v1.11 model predicts no effects at saturated concentrations in water for TGEPO (CAS No. 83547-95-9). The estimated logKow for this substance is greater than the class specific cut-offs for acute fish toxicity, and the predicted effect level exceeds the estimated water solubility of this substance by more than 10x.
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