Boronic acid, (4-ethylphenyl)-

Adsorption / desorption

Link to relevant study record(s)

Reference

Endpoint:

adsorption / desorption: screening

Type of information:

experimental study

Adequacy of study:

key study

Study period:

2006-08-31 to 2006-11-14

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 121 (Estimation of the Adsorption Coefficient (Koc) on Soil and on Sewage Sludge using High Performance Liquid Chromatography (HPLC))

Version / remarks:

2001

Deviations:

no

Qualifier:

according to guideline

Guideline:

EU Method C.19 (Estimation of the Adsorption Coefficient (KOC) on Soil and Sewage Sludge Using High Performance Liquid Chromatography (HPLC))

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Type of method:

HPLC estimation method

Media:

other: HPLC standards

Test temperature:

27 °C

Details on study design: HPLC method:

EQUIPMENT
- Apparatus: HPLC System

- Column:
Stationary phase: LiChrospher 100 CN
Material: stainless steel

- Detection system: UV-Vis detector

MOBILE PHASES
- Type: Methanol, cleaned water 50:50 % (v/v)
- pH: 6.6

DETERMINATION OF DEAD TIME
- Method: The dead time is determined by using a "dead time marker".

Key result

Type:

Koc

Value:

39.811 L/kg

pH:

6.6

Temp.:

27 °C

Key result

Type:

log Koc

Value:

1.6 dimensionless

pH:

6.6

Temp.:

27 °C

Individual Results

Table 1: Determination of the Dead Time t₀

 

Dead time marker	tR in min. 1. Measurement	tR in min. 2. Measurement	tR in min. Mean
Formamide	3.65	3.65	3.65

 

Dead time: t₀ = 3.65 min

 

Table 2: Calibration Data - 1. Measurement

 

Calibration substance	1. lnj. tR in min	k	logk	log Koc *
Acetanilide	4.82	0.32	-0.49	1.25
Atrazin	5.45	0.49	-0.31	1.81
Monuron	5.77	0.58	-0.23	1.99
Triadimenol	6.86	0.88	-0.06	2.40
Linuron	7.90	1.17	0.07	2.59
Pyrazophos	11.77	2.23	0.35	3.65
Diclofop-methyl	15.03	3.12	0.49	4.20

 

Regression: logK_oc = a + b x logk

Parameters: a = 2.63

b = 2.91

r² = 0.9866

 

Table 3: log K_oc of the Test Item - 1. Measurement

 

Substance	1. lnj.tR in min	k	Logk	log Koc
Test item	5.27	0.45	-0.35	1.61

 

Table 4: Calibration Data - 2. Measurement

 

Calibration substance	2. Inj. tR in min	k	log k	log Koc *
Acetanilide	4.82	0.32	-0.49	1.25
Atrazin	5.46	0.50	-0.30	1.81
Monuron	5.78	0.59	-0.23	1.99
Triadimenol	6.88	0.89	-0.05	2.40
Linuron	7.93	1.18	0.07	2.59
Pyrazophos	11.86	2.25	0.35	3.65
Diclofop-methyl	15.14	3.15	0.50	4.20

(*from OECD guideline 121, adopted January 2001)

Regression: logK_oc = a + b x logk

Parameters: a = 2.62

b = 2.89

r² = 0.9865

 

Table 5: log K_oc of the Test Item - 2. Measurement

 

Substance	2. Inj. tR in min	k	Log k	log Koc
Test item	5.34	0.46	-0.33	1.66

 

Table 6: log K_oc of the Test Item

 

	log Koc
1. Measurement	1.61
2. Measurement	1.66
Mean	1.63

Validity criteria fulfilled:

yes

Conclusions:

The adsorption coefficient of the test item was found to be log Koc = 1.6. The Koc was calculated to be 39.8107 L/kg.

Executive summary:

The adsorption coefficient of the test item was determined according to the HPLC method described in the EU Method C.19 and OECD TG 121. Under the test conditions, the adsorption coefficient of the test item was found to be log K_oc = 1.6. The Koc was calculated to be 39.8107 L/kg.

Description of key information

The adsorption coefficient of the test item was found to be log K_oc = 1.6. The Koc was calculated to be 39.8107 L/kg (reference 5.4.1-1).

Key value for chemical safety assessment

Koc at 20 °C:

39.811

Additional information

The adsorption coefficient of the test item was determined according to the HPLC method described in the EU Method C.19 and OECD TG 121. Under the test conditions, the adsorption coefficient of the test item was found to be log K_oc = 1.6. The Koc was calculated to be 39.8107 L/kg.