Registration Dossier
Registration Dossier
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EC number: 263-196-9 | CAS number: 61791-64-8
Endpoint summary
Administrative data
Description of key information
Fish: The LC50 (96 h) value was determined to be 0.84 mg/L (OECD 203).
Additional information
Fish
A key study was undertaken in accordance with PARCOM Method 1995 and OECD 203 (1992) “Fish, Acute Toxicity Test” to determine the toxicity of the test item to juvenile turbot, Scophthalmus maximus, which is the test organism recommended by the Paris Commission for studies on the effects of test chemicals on marine vertebrates.
Single replicates of 10 L at nominal test concentrations of 0.1, 0.178, 0.316, 0.562 and 1.0 mg/L in artificial seawater and control media were prepared. Seven animals were added to each test vessel and exposures were conducted under semi-static conditions with replacement of media every 48 hours. Test duration was 96 hours at a nominal temperature of 15±1.5°C. Animals were observed twice every 24 hours. Numbers of mortalities and animals exhibiting abnormal behaviour were recorded. At the end of the test, a sample of juvenile turbot was weighed and measured. The mean values and standard deviations were calculated and recorded.
All animals in the control vessels survived the 96-hour test period. After 96 hours exposure to the specified test concentrations, the LC50 was determined to be 0.84 mg/L. The 72-hour LC50 value was determined to be 0.93 mg/L. The 24 and 48-hour LC50 values were both determined to be > 1.0 mg/L.
The concentration of test material producing no observable effect (NOEC) was determined to be 0.562 mg/L after 96 hours. The concentration of test item producing the Lowest Observed Effect (LOEC) was determined to be 1.0 mg/L after 96 hours.
Aquatic invertebrates: Investigation of short-term toxicity to Daphnia magna is ongoing and relevant publicly available data are not available. PNECs required for risk assessment are therefore based on current company prediction (0.032 mg/L).
Algae: Investigation of algal growth rate inhibition is ongoing and relevant publicly available data are not available. PNECs required for risk assessment are therefore based on current company prediction (0.023 mg/L).
Microorganisms: Investigation of activated sludge respiration inhibition is in progress.
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