3,7-dimethyloctane-1,7-diol

Toxicity to reproduction

Administrative data

Endpoint:

screening for reproductive / developmental toxicity

Data waiving:

study scientifically not necessary / other information available

Justification for data waiving:

other:

Justification for type of information:

A screening study for reproductive/developmental toxicity does not need to be conducted because there is no evidence from available information (e.g. (Q)SAR) that the substance may be a developmental toxicant.
The acute oral toxicity of the test item is very low (LD50: > 5 mL/kg). Also in a study with repeated oral dosing over 28 consecutive days no adverse clinical effects or histopathological findings were seen in rats dosed with up to 1000 mg/kg (NOAEL: > 1000 mg/kg). As also reported in the attached (Q)SAR predicted profile, the test item does not suggest a specific alert for a teratogenic potential in humans. Therefore, at present there is no need to perform a screening study for reproductive/developmental toxicity in experimental animals.

Materials and methods

Test material

Test material information

Constituent 1

Reference substance name:

3,7-dimethyloctane-1,7-diol

EC Number:

203-517-1

EC Name:

3,7-dimethyloctane-1,7-diol

Cas Number:

107-74-4

Molecular formula:

C10H22O2

IUPAC Name:

3,7-dimethyloctane-1,7-diol

Test material form:

liquid