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Physical & Chemical properties

Water solubility

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Reference
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
25 July 2008 to 17 November 2008
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: Study conducted to GLP in compliance with agreed protocols, with no or minor deviations from standard test guidelines and/or minor methodological deficiencies, which do not affect the quality of the relevant results.
Qualifier:
according to guideline
Guideline:
EU Method A.6 (Water Solubility)
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Type of method:
flask method
Water solubility:
50.9 g/L
Temp.:
20 °C
pH:
2.16
Remarks on result:
other: pH value is the average of 3 samples

Preliminary Test

The preliminary estimate of water solubility was 52.6 g/L.

 

Definitive Test

Table 2: Concentration (g/L) of test material in sample solution:

 

Sample Number

 

Time Shaken at

30°C (hours)

 

Time Equilibrated at

20°C (hours)

 

Concentration(g/L)

 

Solution pH

1

24

24

52.1

2.2

2

48

24

51.1

2.2

3

72

24

49.6

2.1

- Mean concentration: 50.9 g/L at 20.0 ± 0.5 °C

- Range: 49.6 to 52.1 g/L

Conclusions:
Under the conditions of the study, the water solubility of the test material has been determined to be 50.9 g/L of solution at 20.0 ± 0.5 °C.
Executive summary:

The solubility of the test material was investigated in a study which was conducted under GLP conditions and in accordance with the standardised guidelines EU Method A.6., following the shake flask method.

Under the conditions of the study, the water solubility of the test material has been determined to be 50.9 g/L of solution at 20.0 ± 0.5 °C.

Description of key information

Water solubilty = 50.9 g/L at 20.0 ± 0.5 °C, EU Method A.6. (shake flask), Butler & O'Connor (2008)

Key value for chemical safety assessment

Water solubility:
50.9 g/L
at the temperature of:
20 °C

Additional information

The solubility of the test material was investigated in a study which was conducted under GLP conditions and in accordance with the standardised guidelines EU Method A.6., following the shake flask method. The study was assigned a reliability score of 1 in line with the principles for assessing data quality as defined by Klimisch (1997).

Under the conditions of the study, the solubility of the test material, has been determined to be 50.9 g/L of solution at 20.0 ± 0.5 °C.