Dihydrogen [[N,N'-ethylenebis[N-(carboxymethyl)glycinato]](4-)-N,N',O,O',ON,ON']nickelate(2-)

Endpoint summary

Description of key information

Biodegradation in water: screening test: The biodegradability of the substance was calculated using seven different Biowin 1-7 models of the BIOWIN v4.10 software. The results indicate that the test chemical is expected to be 50 % biodegradable in 3.5395 weeks hence consider as not readily biodegradable.

Biodegradation in water: simulation tests: Estimated half life of test chemical in water was 37.5 days, 900 hr. 

Biodegradation in sediment: simulation tests: Estimated half life of test chemical in sediment estimated to be 337.5 days, 8100 hr.

Biodegradation in soil : The biodegradation half-life of test substance in soil was estimated to be (75) days, 1800 hrs.

Additional information

Biodegradation in water: screening test: 

Predicted data of target chemical and supporting weight of evidence studies for it's  structurally similar read across chemicals has been reviewed to determine the effect of the test chemical on biodegradation. The studies are as mentioned below:

The first study includes Estimation Programs Interface Suite was run to predict the biodegradation potential of the test compound in the presence of mixed populations of environmental microorganisms. The biodegradability of the substance was calculated using seven different models such as Linear Model, Non-Linear Model, Ultimate Biodegradation Timeframe, Primary Biodegradation Timeframe, MITI Linear Model, MITI Non-Linear Model and Anaerobic Model (called as Biowin 1-7, respectively) of the BIOWIN v4.10 software. The results indicate that the test chemical is expected to be 50 % biodegradable in 3.5395 weeks hence consider as not readily biodegradable.

The second study of biodegradation was also carried out. Duration of test was 28 days . Activated sludge was taken as inoculum. Concentration of sludge was taken as 30 mg/l. Concentration of test chemical was taken as 100 mg/l. Test chemical reached 0% degradation by O2 consumption parameter, in duration of 28 days. Thus test chemical was considered as not readily biodegradable in water. 

On the basis of information mentioned above, the test chemical was considered as not readily biodegradable in water. 

Biodegradation in water: simulation tests: Estimation Programs Interface prediction model was run to predict the half-life in water and sediment for the test compound. If released in to the environment,  50 % of the chemical will partition into water according to the Mackay fugacity model level III and the half-life period of test chemical in water is estimated to be  37.5 days ( 900  hrs). The half-life ( 37.5    days estimated by EPI suite) indicates that the chemical is  not persistent in water and the exposure risk to aquatic animals is moderate to low. 

Biodegradation in sediment: simulation tests: Estimation Programs Interface  prediction model was run to predict the half-life in  sediment for the test compound. The half-life period of test chemical in sediment is estimated to be  337.5 days ( 8100 hrs).  However, as the percentage release of test chemical into the sediment is less than 1% (i.e, reported as  0.0835  %), indicates that test chemical is not persistent in sediment.

 

Biodegradation in soil : The half-life period of test chemical  in soil was estimated using Level III Fugacity Model by EPI Suite version 4.1 estimation database (EPI suite, 2017). If released into the environment, 50 % of the chemical will partition into soil according to the Mackay fugacity model level III. The half-life period of test chemical in soil is estimated to be 75 days (1800 hrs). Based on this half-life value of test chemical, it is concluded that the chemical is not persistent in the soil environment and the exposure risk to soil dwelling animals is moderate to low.